Ultrastructure study of hair damage after ultraviolet irradiation
Article first published online: 4 DEC 2013
© 2013 Wiley Periodicals, Inc.
Journal of Cosmetic Dermatology
Volume 12, Issue 4, pages 254–260, December 2013
How to Cite
Zuel-Fakkar, N. M., El Khateeb, E. A., Cousha, H. S. and Hamed, D. M. (2013), Ultrastructure study of hair damage after ultraviolet irradiation. Journal of Cosmetic Dermatology, 12: 254–260. doi: 10.1111/jocd.12068
- Issue published online: 4 DEC 2013
- Article first published online: 4 DEC 2013
- Manuscript Accepted: 25 AUG 2013
- narrow band-ultraviolet B;
- psoralen and UVA;
Natural ultraviolet exposure induces hair damage, which is difficult to avoid. Most of the research work is focused on the effect of ultraviolet on the epidermis, dermis as well as the immune system, whereas the long-term effect of ultraviolet on hair has not been investigated.
Aim: we performed our experiment to find out the changes induced in hair follicle and shaft in those patients exposed to high doses of ultraviolet (A and B) during treatment of other skin conditions.
Patients and Methods
Light and transmission electron microscopy examination of scalp hair follicles and shafts of 10 patients with vitiligo under psoralen plus ultraviolet A (group 1) and 10 patients with vitiligo under narrow band ultraviolet B (group 2) was carried out and compared with those of 10 healthy volunteers (group 3).
Physical changes in the appearance of hair were more in groups 1 and 2 than control. Reduced hair follicle thickness and perifollicular infiltrate and hyaline disorganized perifollicular collagen were observed more in group 1 than in group 2 with the absence of these changes in group 3. Transmission electron microscopy showed nonspecific cell injury in hair follicles in group 1 more than the other 2 groups, while the damaging effect on hair was more in the second group than the others.
Due to the damaging effect of ultraviolet on hair, patients under treatment with this modality should be cautious to protect their hair during treatment.