Health care for adolescents and young people
Insulin resistance and inflammation markers: correlations in obese adolescents
Article first published online: 6 DEC 2012
© 2012 Blackwell Publishing Ltd
Journal of Clinical Nursing
Volume 22, Issue 13-14, pages 2002–2010, July 2013
How to Cite
Aguilar, M. J., González-Jiménez, E., Antelo, A. and Perona, J. S. (2013), Insulin resistance and inflammation markers: correlations in obese adolescents. Journal of Clinical Nursing, 22: 2002–2010. doi: 10.1111/jocn.12034
- Issue published online: 8 JUN 2013
- Article first published online: 6 DEC 2012
- Manuscript Accepted: 11 AUG 2012
- Ayuntamiento de Guadix
- Spanish Ministry of Science and Innovation. Grant Number: AGL2011-23810
- Hospital San Cecilio
- homoeostasis model assessment for insulin resistance;
- insulin resistance;
Aims and objectives
To ascertain whether inflammation markers also correlate with parameters related to insulin resistance and the metabolic syndrome in a group of adolescents.
Obesity is now considered a chronic low-grade inflammatory process, characterised by alterations in the systemic concentrations of some inflammation markers. Adiponectin, leptin and other inflammatory proteins have been shown to correlate with insulin resistance and the metabolic syndrome in adults.
Cross-sectional study in two groups of obese and normal weight adolescents.
Serum levels of adiponectin, leptin, ceruloplasmin and insulin levels were determined and correlated among them and with anthropometric parameters, blood pressure body mass index and body mass index z-score.
Waist circumference, body mass index and blood pressure values correlated significantly with both homoeostasis model assessment for insulin resistance and insulin levels. Ceruloplasmin also correlated with both parameters with a high level of significance. However, leptin levels did not correlate with either homoeostasis model assessment for insulin resistance or insulin, and adiponectin correlated with homoeostasis model assessment for insulin resistance but not insulin. All inflammation markers studied correlated with the body mass index z-score. These correlations were stronger in the group of obese individuals compared to lean ones.
We found a relationship between insulin resistance and some inflammation in adolescents, which was particularly strong in obese individuals and was associated with the development of metabolic syndrome. Among the inflammation markers studied, ceruloplasmin revealed as a potential string marker of insulin resistance in obese adolescents.
Relevance to clinical practice
The results obtained in this study imply a significant advance in the field of clinical practice of nursing. The adequate understanding by nursing personnel of the inflammatory processes inherent to obesity constitutes a key factor for the prevention of the disease and its complications in adolescents.