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Effectiveness of a nurse-led intensive educational programme on chronic kidney failure patients with hyperphosphataemia: randomised controlled trial


Correspondence: Yue Zhao, Nursing College, Tianjin Medical University, Observatory Road, Heping district, Tianjin, China. Telephone: +86 022 83336901.



Aims and objectives

To prospectively evaluate the effects of a nurse-led educational intervention on the management of hyperphosphataemia as well as knowledge of phosphate among patients with end-stage renal disease.


Haemodialysis and phosphate binder therapy are the major methods used to reduce the phosphate level in dialysis patients. However, patient education related to hyperphosphataemia, diet and phosphate binders may be another important factor associated with the success of the control of the hyperphosphataemia.


This prospective randomised controlled trial was conducted during the period from June 2009–March 2011 at the HD units of two hospitals in Tianjin, China.


A total of 80 participants were randomly assigned to experimental group (n = 40) and control group (n = 40). Participants in the experimental group received the nurse-led intensive educational programme, including individualised education and educational session about diet and medicine regimes, etc., while participants in the control group received the routine guidance.


There were statistically significant differences between the study groups in decline in serum phosphorus and calcium–phosphorus product levels and improvement in patients' general knowledge three months postintervention, and these differences sustained until the end of the study. Increased serum calcium level was observed both in the experimental group and in the control group, but there was no significant difference between groups. No statistical significance was found regarding serum albumin level between the groups. No significant difference in the serum parathyroid hormone level was found between the groups by month 6.


Nurse-led intensive educational programme plays an important role in the control of hyperphosphataemia among patients with end-stage renal disease.

Relevance to clinical practice

Chronic kidney failure patients with hyperphosphataemia are more likely to benefit from nurse-led intensive educational programmes.