Conflict of interest: The authors have no conflict of interest.
Humoral hypercalcemia caused by uterine corpus carcinosarcoma consisting of squamous cell carcinoma in its epithelial component
Article first published online: 5 SEP 2013
© 2013 The Authors. Journal of Obstetrics and Gynaecology Research © 2013 Japan Society of Obstetrics and Gynecology
Journal of Obstetrics and Gynaecology Research
Volume 40, Issue 1, pages 263–267, January 2014
How to Cite
Takamatsu, S., Matsumura, N., Baba, T., Mandai, M., Mikami, Y. and Konishi, I. (2014), Humoral hypercalcemia caused by uterine corpus carcinosarcoma consisting of squamous cell carcinoma in its epithelial component. Journal of Obstetrics and Gynaecology Research, 40: 263–267. doi: 10.1111/jog.12136
- Issue published online: 1 JAN 2014
- Article first published online: 5 SEP 2013
- Manuscript Accepted: 25 MAR 2013
- Manuscript Received: 7 NOV 2012
- parathyroid hormone-related protein;
- squamous cell carcinoma;
- uterine neoplasms
Humoral hypercalcemia of malignancy (HHM) is a paraneoplastic syndrome primarily caused by a tumor-producing parathyroid hormone-related protein (PTH-rP). We describe the first reported case of a uterine carcinosarcoma causing HHM. A 70-year-old patient was transferred to our hospital for a uterine tumor accompanied by impaired consciousness. The laboratory tests indicated anemia, malnutrition, elevated serum calcium and elevated PTH-rP. Emergency surgery, including abdominal hysterectomy and bilateral salpingo-oophorectomy, was performed due to uncontrollable uterine bleeding. The pathological diagnosis was carcinosarcoma consisting of pure squamous cell carcinoma in its epithelial component. Postoperatively, chemotherapy with paclitaxel and carboplatin was performed. The patient had recurrent tumors at the para-aortic lymph nodes 11 months after the initial surgery and underwent a pelvic and para-aortic lymphadenectomy, which removed all of the recurrent tumors.