These authors are dual senior authors.
Effects of individual and combined dietary weight loss and exercise interventions in postmenopausal women on adiponectin and leptin levels
Article first published online: 29 MAR 2013
© 2013 The Association for the Publication of the Journal of Internal Medicine
Journal of Internal Medicine
Volume 274, Issue 2, pages 163–175, August 2013
How to Cite
National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany; Fred Hutchinson Cancer Research Center, Seattle, WA, USA; National Cancer Institute/National Institutes of Health, Bethesda, MD, USA; University of Washington, Seattle, WA, USA; University of British Columbia, Vancouver, BC, Canada; University of Washington, Seattle, WA, USA; Washington University School of Medicine, St. Louis, MO, USA; University of Washington, Seattle, WA, USA; Massey University, Wellington, New Zealand; Harvard Medical School, Boston, MA, USA; University of Illinois at Chicago, Chicago, IL, USA. Effects of individual and combined dietary weight loss and exercise interventions in postmenopausal women on adiponectin and leptin levels. J Intern Med 2013; 274: 163–175., , , , , , , , , , , , , ,
- Issue published online: 12 JUL 2013
- Article first published online: 29 MAR 2013
- Accepted manuscript online: 25 FEB 2013 06:15AM EST
- National Cancer Institute at the National Institutes of Health. Grant Numbers: U54-CA116847, R01 CA102504, 5KL2RR025015-03, R25 CA94880, R25CA057699
Vol. 276, Issue 4, 418, Article first published online: 20 SEP 2014
- diet and exercise intervention;
- randomized controlled trial
Excess body weight and a sedentary lifestyle are associated with the development of several diseases, including cardiovascular disease, diabetes and cancer in women. One proposed mechanism linking obesity to chronic diseases is an alteration in adipose-derived adiponectin and leptin levels. We investigated the effects of 12-month reduced calorie, weight loss and exercise interventions on adiponectin and leptin concentrations.
Overweight/obese postmenopausal women (n = 439) were randomized as follows: (i) a reduced calorie, weight-loss diet (diet; N = 118), (ii) moderate-to-vigorous intensity aerobic exercise (exercise; N = 117), (iii) a combination of a reduced calorie, weight-loss diet and moderate-to-vigorous intensity aerobic exercise (diet + exercise; N = 117), and (iv) control (N = 87). The reduced calorie diet had a 10% weight-loss goal. The exercise intervention consisted of 45 min of moderate-to-vigorous aerobic activity 5 days per week. Adiponectin and leptin levels were measured at baseline and after 12 months of intervention using a radioimmunoassay.
Adiponectin increased by 9.5% in the diet group and 6.6% in the diet + exercise group (both P ≤ 0.0001 vs. control). Compared with controls, leptin decreased with all interventions (diet + exercise, −40.1%, P < 0.0001; diet, −27.1%, P < 0.0001; exercise, −12.7%, P = 0.005). The results were not influenced by the baseline body mass index (BMI). The degree of weight loss was inversely associated with concentrations of adiponectin (diet, P-trend = 0.0002; diet + exercise, P-trend = 0.0005) and directly associated with leptin (diet, P-trend < 0.0001; diet + exercise, P-trend < 0.0001).
Weight loss through diet or diet + exercise increased adiponectin concentrations. Leptin concentrations decreased in all of the intervention groups, but the greatest reduction occurred with diet + exercise. Weight loss and exercise exerted some beneficial effects on chronic diseases via effects on adiponectin and leptin.