• 1
    Zheng ZJ, Croft JB, Giles WH, Mensah GA. Sudden cardiac death in the United States, 1989 to 1998. Circulation 2001; 104: 215863.
  • 2
    2011 report from the Swedish Cardiac Arrest Register. Available at: (accessed September 30, 2012).
  • 3
    Atwood C, Eisenberg MS, Herlitz J, Rea TD. Incidence of EMS- treated out-of-hospital cardiac arrest in Europe. Resuscitation 2005; 67: 7580.
  • 4
    Rea TD, Eisenberg MS, Sinibaldi G, White RD. Incidence of EMS treated out of-hospital cardiac arrest in the United States. Resuscitation 2004; 63: 1724.
  • 5
    Muller D, Agrawal R, Arntz HR. How sudden is sudden cardiac death? Circulation 2006; 114: 114650.
  • 6
    Vreede-Swagemakers JJ, Gorgels AP, Dubois-Arbouw WI et al. Out-of-hospital cardiac arrest in the 1990s: a population-based study in the Maastricht area on incidence, characteristics and survival. J Am Coll Cardiol 1997; 30: 15005.
  • 7
    Kannel WB, Cupples LA, D'Agostino RB. Sudden death risk in overt coronary heart disease: the Framingham Study. Am Heart J 1987; 113: 799804.
  • 8
    United Kingdom Heart Attack Study Collaborative Group, Norris RM. Fatality outside hospital from acute coronary events in three British health districts, 1994–1995. Br Med J 1998; 316: 106570.
  • 9
    ESC guidelines on device therapy in heart failure. Available at: (accessed Sep-tember 30, 2012).
  • 10
    Hollenberg J, Herlitz J, Lindqvist J et al. Improved survival after out-of-hospital cardiac arrest is associated with an increase in proportion of emergency crew–witnessed cases and bystander cardiopulmonary resuscitation. Circulation 2008; 118: 38996.
  • 11
    Rea TD, Eisenberg MS, Becker LJ, Murray JA, Hearne T. Temporal trends in sudden cardiac arrest: a 25-year emergency medical services perspective. Circulation 2003; 107: 27805.
  • 12
    Kette F, Pordenone Cardiac Arrest Cooperative Study Group (PACS). Increased survival despite a reduction in out-of-hospital ventricular fibrillation in north-east Italy. Resuscitation 2007; 72: 528.
  • 13
    Cummins RO, Chamberlain DA, Abramson NS et al. Recommended guidelines for uniform reporting of data from out-of-hospital cardiac arrest: the Utstein Style. A statement for health professionals from a task force of the American Heart Association, the European Resuscitation Council, the Heart and Stroke Foundation of Canada, and the Australian Resuscitation Council. Circulation 1991b; 84: 96075.
  • 14
    Ruppert M, Reith MW, Widmann JH et al. Checking for breathing: evaluation of the diagnostic capability of emergency medical services personnel, physicians, medical students, and medical laypersons. Ann Emerg Med 1999; 34: 7209.
  • 15
    Perkins GD, Stephenson B, Hulme J, Monsieurs KG. Birmingham assessment of breathing study (BABS). Resuscitation 2005; 64: 10913.
  • 16
    Bohm K, Rosenqvist M, Hollenberg J, Biber B, Engerström L, Svensson L. Dispatcher-assisted telephone-guided cardiopulmonary resuscitation: an underused lifesaving system. Eur J Emerg Med 2007; 14: 2569.
  • 17
    Bobrow BJ, Zuercher M, Ewy GA et al. Gasping during cardiac arrest in humans is frequent and associated with improved survival. Circulation 2008; 118: 25504.
  • 18
    Bohm K, Stålhandske B, Rosenqvist M, Ulfvarson J, Hollenberg J, Svensson L. Tuition of emergency medical dispatchers in the recognition of agonal respiration increases the use of telephone assisted CPR. Resuscitation 2009; 80: 10258.
  • 19
    Harve H, Jokela J, Tissari A et al. Can untrained laypersons use a defibrillator with dispatcher assistance? Acad Emerg Med 2007; 14: 6248.
  • 20
    Rea TD, Eisenberg MS, Culley LL, Becker L. Dispatcher-assisted cardiopulmonary resuscitation and survival in cardiac arrest. Circulation 2001; 104: 25136.
  • 21
    Chan PS, Jain R, Nallmothu BK, Berg RA, Sasson C. Rapid response teams: a systematic review and meta-analysis. Arch Intern Med 2010; 170: 1826.
  • 22
    ERC guidelines 2010. Available at: (accessed September 30, 2012).
  • 23
    Lund I, Skulberg A. Cardiopulmonary resuscitation by lay people. Lancet 1976; 2: 7024.
  • 24
    Larsen MP, Eisenberg MS, Cummins RO, Hallstrom AP. Predicting survival from out-of-hospital cardiac arrest: a graphic model. Ann Emerg Med 1993; 22: 16528.
  • 25
    Herlitz J, Engdahl J, Svensson L, Angquist KA, Young M, Holmberg S. Factors associated with an increased chance of survival among patients suffering from an out-of-hospital cardiac arrest in a national perspective in Sweden. Am Heart J 2005a; 149: 616.
  • 26
    Cobb LA, Fahrenbruch CE, Walch TT et al. Influence of cardiopulmonary resuscitation prior to defibrillation in patients with out-of-hospital ventricular fibrillation. JAMA 1999; 28: 11828.
  • 27
    Waalewijn RA, Nijpels MA, Tijssen JG, Koster RW. Prevention of deterioration of ventricular fibrillation by basic life support during out-of-hospital cardiac arrest. Resuscitation 2002; 54: 316.
  • 28
    Nordberg P, Hollenberg J, Herlitz J, Rosenqvist M, Svensson L. Aspects on the increase in bystander CPR in Sweden and its association with outcome. Resuscitation 2009; 80: 32933.
  • 29
    Anonymous. European Resuscitation Council Guidelines 2000 for adult basic life support. Part 3: adult basic life support. Resuscitation 2000a; 46: 2971.
  • 30
    Anonymous. European Resuscitation Council Guidelines for Resuscitation 2005 Section 2. Adult basic life support and use of automated external defibrillators. Resuscitation 2005a; 67(Suppl 1): S723.
  • 31
    Berg RA, Kern KB, Hilwig RW et al. Assisted ventilation does not improve outcome in a porcine model of single-rescuer bystander cardiopulmonary resuscitation. Circulation 1997; 95: 163541.
  • 32
    Hallstrom A, Cobb L, Johnson E, Copass M. Cardiopulmonary resuscitation by chest compression alone or with mouth-to-mouth ventilation. N Engl J Med 2000; 342: 154653.
  • 33
    Bohm K, Rosenqvist M, Herlitz J, Hollenberg J, Svensson L. Survival is similar after standard treatment and chest compression only in out-of-hospital bystander cardiopulmonary resuscitation. Circulation 2007a; 116: 290812.
  • 34
    Iwami T, Kawamura T, Hiraide A et al. Effectiveness of bystander-initiated cardiac-only resuscitation for patients with out-of-hospital cardiac arrest. Circulation 2007; 116: 29007.
  • 35
    Svensson L, Bohm K, Castrèn M et al. Compression-only CPR or standard CPR in out-of-hospital cardiac arrest. N Engl J Med 2010; 363: 43442.
  • 36
    Rea TD, Fahrenbruch C, Culley L et al. CPR with chest compression alone or with rescue breathing. N Engl J Med 2010; 363: 42333.
  • 37
    Bobrow BJ, Spaite DW, Berg RA et al. Chest compression-only CPR by lay rescuers and survival from out-of-hospital cardiac arrest. JAMA 2010; 304: 144754.
  • 38
    Steen S, Sjöberg T, Olsson P, Young M. Treatment of out-of-hospital cardiac arrest with LUCAS, a new device for automatic mechanical compression and active decompression resuscitation. Resuscitation 2005; 67: 2530.
  • 39
    Ikeno F, Kaneda H, Hongo Y et al. Augmentation of tissue perfusion by a novel compression device increases neurologically intact survival in a porcine model of prolonged cardiac arrest. Resuscitation 2006; 68: 10918.
  • 40
    Axelsson C, Nestin J, Svensson L, Axelsson AB, Herlitz J. Clinical consequences of the introduction of mechanical chest compression in the EMS system for treatment of out-of- hospital cardiac arrest-a pilot study. Resuscitation 2006; 71: 4755.
  • 41
    Hallstrom A, Rea TD, Sayre MR et al. Manual chest compression vs use of an automated chest compression device during resuscitation following out-of-hospital cardiac arrest: a randomized trial. JAMA 2006; 295: 26208.
  • 42
    Whitfield R, Colquhoun M, Chamberlain D, Newcombe R, Davies CS, Boyle R. The Department of Health National Defibrillator Programme: analysis of downloads from 250 deployments of public access defibrillators. Resuscitation 2005; 64: 26977.
  • 43
    Hallstrom AP, Ornato JP, Weisfeldt M et al. Public-access defibrillation and survival after out-of-hospital cardiac arrest. N Engl J Med 2004; 351: 63746.
  • 44
    Valenzuela TD, Roe DJ, Nichol G, Clark LL, Spaite DW, Hardman RG. Outcomes of rapid defibrillation by security officers after cardiac arrest in casinos. N Engl J Med 2000; 343: 12069.
  • 45
    Page RL, Joglar JA, Kowal RC et al. Use of automated external defibrillators by a U.S. airline. N Engl J Med 2000; 343: 12106.
  • 46
    Mosesso VN Jr, Davis EA, Auble TE, Paris PM, Yealy DM. Use of automated external defibrillators by police officers for treatment of out-of-hospital cardiac arrest. Ann Emerg Med 1998; 32: 2007.
  • 47
    Stiell IG, Wells GA, Field BJ et al. Improved out-of-hospital cardiac arrest survival through the inexpensive optimization of an existing defibrillation program: OPALS study phase II. Ontario prehospital advanced life support. JAMA 1999; 281: 117581.
  • 48
    Myerburg RJ, Fenster J, Velez M et al. Impact of community-wide police car deployment of automated external defibrillators on survival from out-of-hospital cardiac arrest. Circulation 2002; 106: 105864.
  • 49
    Smith KL, McNeil JJ, Emergency Medical Response Steering Committee. Cardiac arrests treated by ambulance paramedics and fire fighters. Med J Aust 2002; 177: 3059.
  • 50
    van Alem AP, Vrenken RH, de Vos R, Tijssen JG, Koster RW. Use of automated external defibrillator by first responders in out of hospital cardiac arrest: prospective controlled trial. BMJ 2003; 327: 1312.
  • 51
    Sayre MR, Evans J, White LJ, Brennan TD. Providing automated external defibrillators to urban police officers in addition to a fire department rapid defibrillation program is not effective. Resuscitation 2005; 66: 18996.
  • 52
    Hollenberg J, Riva G, Bohm K et al. Dual dispatch early defibrillation in out-of-hospital cardiac arrest: the SALSA-pilot. Eur Heart J 2009; 30: 17819.
  • 53
    Bernard SA, Gray TW, Buist MD et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 2002; 346: 55763.
  • 54
    Anonymous. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. The hypothermia after cardiac arrest study group. N Engl J Med 2002b; 346: 54956.
  • 55
    Langhelle A, Tyvold SS, Lexow K, Hapnes SA, Sunde K, Steen PA. In-hospital factors associated with improved outcome after out-of-hospital cardiac arrest. A comparison between four regions in Norway. Resuscitation 2003; 56: 24763.
  • 56
    Skrifvars MB, Pettila V, Rosenberg PH, Castren M. A multiple logistic regression analysis of in-hospital factors related to survival at six months in patients resuscitated from out-of-hospital ventricular fibrillation. Resuscitation 2003; 59: 31928.
  • 57
    Herlitz J, Castren M, Friberg H et al. Post resuscitation care: what are the therapeutic alternatives and what do we know? Resuscitation 2006; 69: 1522.
  • 58
    Sunde K, Pytte M, Jacobsen D et al. Implementation of a standardised treatment protocol for post resuscitation care after out-of-hospital cardiac arrest. Resuscitation 2007; 73: 2939.
  • 59
    Hollenberg J, Bang A, Lindqvist J et al. Difference in survival after out-of-hospital cardiac arrest between the two largest cities in Sweden: a matter of time? J Intern Med 2005; 257: 24754.
  • 60
    Hollenberg J. Thesis for a doctoral degree. Available at: (accessed September 30, 2012).
  • 61
    Hüpfl M, Selig HF, Nagele P. Chest-compression-only versus standard cardiopulmonary resuscitation: a meta-analysis. Lancet 2010; 376: 15527.
  • 62
    Prutkin JM, Sotoodehnia N. Genetics of sudden cardiac arrest. Prog Cardiovasc Dis 2008; 50: 390403.
  • 63
    Ringh M, Fredman D, Nordberg P, Stark T, Hollenberg J. Mobile phone technology identifies and recruits trained citizens to perform CPR on out-of-hospital cardiac arrest victims prior to ambulance arrival. Resuscitation 2011; 82: 15148.
  • 64
    The Swedish National Agency for Education. Curriculum for the compulsory school, preschool class and the leisure-time centre 2011, pp. 52. Available at: (accessed September 30, 2012).
  • 65
    Isbye DL, Rasmussen LS, Ringsted C, Lippert FK. Disseminating cardiopulmonary resuscitation training by distributing 35,000 personal manikins among school children. Circulation 2007; 116: 13805.
  • 66
    Isbye DL, Meyhoff CS, Lippert FK, Rasmussen LS. Skill retention in adults and in children 3 months after basic life support training using a simple personal resuscitation manikin. Resuscitation 2007; 74: 296302.
  • 67
    Kouwenhoven WB, Jude JR, Knickerbocker GG. Closed-chest cardiac massage. JAMA 1960; 173: 10647.
  • 68
    Brenner B, Stark B, Kauffman J. The reluctance of house staff to perform mouth-to-mouth resuscitation in the inpatient setting: what are the considerations? Resuscitation 1994; 28: 18593.
  • 69
    Ornato JP, Hallagan LF, McMahan SB, Peeples EH, Rostafinski AG. Attitudes of BCLS instructors about mouth-to-mouth resuscitation during the AIDS epidemic. Ann Emerg Med 1990; 19: 1516.
  • 70
    The Swedish Council on Health Technology Assessment (SBU) report on hypothermia. Swedish. Available at: (accessed September 30, 2012).
  • 71
    Nielsen N, Wetterslev J, al-Subaie N et al. Target temperature management after out-of-hospital cardiac arrest–a randomized, parallel-group, assessor-blinded clinical trial–rationale and design. Am Heart J 2012; 163: 5418.
  • 72
    Busch M, Soreide E, Lossius HM, Lexow K, Dickstein K. Rapid implementation of therapeutic hypothermia in comatose out-of-hospital cardiac arrest survivors. Acta Anaesthesiol Scand 2006; 50: 127783.
  • 73
    Storm C, Schefold JC, Kerner T et al. Prehospital cooling with hypothermia caps (PreCoCa): a feasibility study. Clin Res Cardiol 2008; 97: 76872.
  • 74
    Virkkunen I, Yli-Hankala A, Silfvast T. Induction of therapeutic hypothermia after cardiac arrest in prehospital patients using ice-cold Ringer's solution: a pilot study. Resuscitation 2004; 62: 299302.
  • 75
    Castrén M, Nordberg P, Svensson L et al. Intra-arrest transnasal evaporative cooling: a randomized, prehospital, multicenter study (PRINCE: Pre-ROSC IntraNasal cooling effectiveness). Circulation 2010; 122: 72936.
  • 76
    Bernard SA, Smith K, Cameron P et al. Induction of therapeutic hypothermia by paramedics after resuscitation from out-of-hospital ventricular fibrillation cardiac arrest: a randomized controlled trial. Circulation 2010; 122: 73742.
  • 77
    Paradis NA, Martin GB, Rivers EP et al. Coronary perfusion pressure and the return of spontaneous circulation in human cardiopulmonary resuscitation. JAMA 1990; 263: 110613.
  • 78
    Kern KB, Niemman JT, Steen S. Chapter 18, Coronary perfusion pressure during cardiopulmonary resuscitation. In: N. A. Paradis, H. R. Halperin, K. B. Kern, V. Wenzel, D.A. Chamberlain, ed. Cardiac Arrest – The Science of Resuscitation Medicine. New York: Cambridge University Press, 2007; 377.
  • 79
    Ewy GA, Zuercher M, Hilwig RW et al. Improved neurological outcome with continuous chest compressions compared with 30:2 compressions-to-ventilations cardiopulmonary resuscitation in a realistic swine model of out-of-hospital cardiac arrest. Circulation 2007; 116: 252530.
  • 80
    Aufderheide TP, Sigurdsson G, Pirrallo RG et al. Hyperventilation-induced hypotension during cardiopulmonary resuscitation. Circulation 2004; 109: 19605.
  • 81
    ECC Committee, Subcommittees and Task Forces of the American Heart Association. 2005 American Heart /Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation 2005; 112: IV1203.
  • 82
    Chen YS, Lin JW, Yu HY et al. Cardiopulmonary resuscitation with assisted extracorporeal life-support versus conventional cardiopulmonary resuscitation in adults with in-hospital cardiac arrest: an observational study and propensity analysis. Lancet 2008; 372: 55461.
  • 83
    Shin TG, Choi JH, Jo IJ et al. Extracorporeal cardiopulmonary resuscitation in patients with inhospital cardiac arrest: a comparison with conventional cardiopulmonary resuscitation. Crit Care Med 2011; 39: 17.