Individualized therapy for metastatic colorectal cancer

Authors


Correspondence: Lance Liotta, Centre for Applied Proteomics and Molecular Medicine, George Mason University, 10900 University Blvd, MS1A9, Manassas, VA 20110, USA.

(fax: 703-993-8606; e-mail: lliotta@gmu.edu).

Abstract

Systemic therapeutic efficacy is central to determining the outcome of patients with metastatic colorectal cancer (CRC). In these patients, there is a critical need for predictive biomarkers to optimize efficacy whilst minimizing toxicity. The integration of a new generation of molecularly targeted drugs into the treatment of CRC, coupled with the development of sophisticated technologies for individual tumours as well as patient molecular profiling, underlines the potential for personalized medicine. In this review, we focus on the latest progress made within the genomic and proteomic fields, concerning predictive biomarkers for individualized therapy in metastatic CRC.

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