These authors contributed equally to this work.
Muricholic bile acids are potent regulators of bile acid synthesis via a positive feedback mechanism
Version of Record online: 11 OCT 2013
© 2013 The Association for the Publication of the Journal of Internal Medicine
Journal of Internal Medicine
Volume 275, Issue 1, pages 27–38, January 2014
How to Cite
Karolinska Institutet, Stockholm, Sweden). Muricholic bile acids are potent regulators of bile acid synthesis via a positive feedback mechanism. (Rapid Communication). J Intern Med 2014; 275: 27–38., , , (
During the proof editing of this manuscript, a paper by Yu et al.  was published. The authors showed, using a novel in house ELISA that FGF15 plasma levels in normal mice are around 100 pg mL−1, a level in parity with FGF19 levels reported in humans (about 150 pg mL−1) . Therefore, it will now be important to establish to which extent regulation of BA synthesis occurs by direct FGF15/19 actions on the liver versus regulation from direct effects of BAs on this organ.
- Issue online: 12 DEC 2013
- Version of Record online: 11 OCT 2013
- Accepted manuscript online: 30 SEP 2013 09:18AM EST
- Swedish Research Council
- Swedish Heart-Lung Foundation
- Cardiovascular Program
- Karolinska Institutet/Stockholm County Council
Vol. 278, Issue 1, 97, Version of Record online: 15 JUN 2015
Table S1. Effect of AMP on fecal BA excretion in WT and Cyp8b1−/− mice.
Table S2. Effect of AMP on hepatic BA levels in WT and Cyp8b1−/− mice.
Table S3. Effect of BA administration on hepatic BAs in AMP-treated Cyp8b1−/− mice.
|joim12140-sup-0002-FigureS1.pdf||application/PDF||177K||Figure S1. Correlations between ileal FGF15 mRNA and Cyp7a1 mRNA, Cyp7a1 enzymatic activity or ileal ASBT mRNA.|
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