These authors contributed equally. ClinicalTrials.gov Identifier: NCT00211159.
Transfer of omega-3 fatty acids across the blood–brain barrier after dietary supplementation with a docosahexaenoic acid-rich omega-3 fatty acid preparation in patients with Alzheimer's disease: the OmegAD study
Article first published online: 11 JAN 2014
© 2013 The Association for the Publication of the Journal of Internal Medicine
Journal of Internal Medicine
Volume 275, Issue 4, pages 428–436, April 2014
How to Cite
Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm; Uppsala University Hospital, Uppsala, Sweden; and National Institutes of Health, Rockville, MD, USA). Transfer of omega-3 fatty acids across the blood–brain barrier after dietary supplementation with a docosahexaenoic acid-rich omega-3 fatty acid preparation in patients with Alzheimer's disease: the OmegAD study. J Intern Med 2014; 275: 428–436., , , , , , , , , , , (
- Issue published online: 25 MAR 2014
- Article first published online: 11 JAN 2014
- Accepted manuscript online: 23 NOV 2013 01:54AM EST
- The Regional Agreement on Medical Training and Clinical Research
- Stockholm County Council
- Karolinska Institutet. Grant Numbers: 20110263, 20110604
- Funds of Capio
- Gamla Tjänarinnor
- Swedish Alzheimer Foundation
- Odd Fellow Sweden
- Swedish Nutrition Foundation
- Gun och Bertil Stohnes Foundation
- Swedish Society of Physicians
- Lion's Sweden
- Pronova Biocare A/S
Appendix S1. Supplementary information on Material and Methods and Results.
Figure S1. Effects of n-3 fatty acid (FA) supplementation for 6 months on plasma (top) and CSF (bottom) concentrations of linoleic, arachidonic, EPA, EPA, their intermediary 22 : 5 n-3 (DPA n-3) and concentrations of all n-3 FA. Data are given as relative concentrations of the FAs.
Table S1. Data on inflammatory and dementia biomarkers in CSF and measure of cognition.
Table S2. Mean (and 95% CI) values for CSF fatty acids at start (before supplementation with a DHA rich n-3 FA preparation) in relation to values of cognitive functions, assessed by the Mini-Mental State Examination (MMSE).
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