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Figure S1. Manhattan plot of change in UA for African Americans in the discovery cohort from the OmniQuad Chip.

Figure S2. Manhattan plot of change in UA for Caucasians in the discovery cohort from the OmniQuad Chip.

Figure S3. Manhattan plot of change in UA for African Americans in the discovery cohort from the CVD Chip.

Figure S4. Manhattan plot of change in UA for Caucasians in the discovery cohort from the CVD Chip.

Figure S5. Risk score distribution in African Americans.

Figure S6. HCTZ-induced elevation in UA by risk score in African Americans.

Figure S7. Ingenuity pathway analysis software predicted interaction pathways of top genes identified by this study.

Table S1. Risk of new-onset hyperuricemia following HCTZ exposure.

Table S2. Association of top SNPs with baseline UA.

Table S3. Univariate analysis of candidate predictors of HCTZ-induced UA elevation in African Americans.

Table S4. Baseline characteristics of the PEAR expression study subjects.

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