Prospective, randomized, double-blind, clinical evaluation of Aloe vera Barbadensis, applied in combination with a tongue protector to treat burning mouth syndrome
Article first published online: 7 SEP 2012
© 2012 John Wiley & Sons A/S. All rights reserved
Journal of Oral Pathology & Medicine
Volume 42, Issue 4, pages 295–301, April 2013
How to Cite
J Oral Pathol Med (2012) 42: 295−301
- Issue published online: 1 APR 2013
- Article first published online: 7 SEP 2012
- Manuscript Accepted: 27 JUL 2012
- aloe vera;
- quality of life;
- topical treatment
The aim of this study was to evaluate the efficacy of aloe vera (AV) applied in combination with a tongue protector, comparing this with a placebo.
A total of 75 patients with burning mouth syndrome (BMS) were divided into three groups randomly: Group I (tongue protector three times a day), Group II (tongue protector and 0.5 ml AV at 70% three times a day) and Group III (tongue protector and 0.5 ml placebo three times a day). Symptoms were evaluated by visual analogue scale (VAS), while patient psychological profiles were assessed using the Hospital Anxiety-Depression scale and their quality of life using the Oral Health Impact Profile 49 (OHIP-49). Treatment continued for 3 months.
Visual analogue scale pain values improved for all three study groups but without statistically significant differences between the groups (P = 0.210). Regarding quality of life, no significant differences were found between groups with the exception of the OHIP-49 score for handicap. The overall clinical improvement was greater for Group II, with a difference almost reaching significance.
The concomitant prescription of tongue protector and AV is effective for treating patients with BMS.