Laboratory methods and biomarkers in the evaluation of bisphosphonate effects on body tissues: a literature review

Authors

  • Ana Carolina Uchoa Vasconcelos,

    1. Postgraduate Program, Dental College, Pontifical Catholic University of Rio Grande do Sul - PUCRS, Porto Alegre, RS, Brazil
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  • Soraya de Azambuja Berti-Couto,

    1. Postgraduate Program, Dental College, Pontifical Catholic University of Rio Grande do Sul - PUCRS, Porto Alegre, RS, Brazil
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  • Maria Antonia Figueiredo,

    1. Postgraduate Program, Dental College, Pontifical Catholic University of Rio Grande do Sul - PUCRS, Porto Alegre, RS, Brazil
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  • Fernanda Gonçalves Salum,

    1. Postgraduate Program, Dental College, Pontifical Catholic University of Rio Grande do Sul - PUCRS, Porto Alegre, RS, Brazil
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  • Tiago Giuliani Lopes,

    1. Department of Pathology, School of Medicine, Hospital São Lucas, Pontifical Catholic University of Rio Grande do Sul - PUCRS, Porto Alegre, RS, Brazil
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  • Karen Cherubini

    Corresponding author
    • Postgraduate Program, Dental College, Pontifical Catholic University of Rio Grande do Sul - PUCRS, Porto Alegre, RS, Brazil
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Correspondence: Karen Cherubini, Serviço de Estomatologia, Hospital São Lucas PUCRS, Av Ipiranga, 6690, sala 231, Porto Alegre, RS, Brazil. CEP: 90610-000, Tel/Fax: 55(51)33203254, E-mail: karen.cherubini@pucrs.br

Abstract

Bisphosphonates are extensively used to treat bone metabolism disorders; meanwhile, these drugs have important side effects such as jaw osteonecrosis and femoral fracture. Therefore, studies have been conducted aimed at better understanding their mechanism of action and determining a course of action to avoid these side effects. We present here a literature review focusing on the laboratory methods available for investigating bisphosphonate effects on body tissues. There are many different methods available for this purpose, but the appropriate application of these methods and knowledge of their limitations are crucial for understanding the effects of bisphosphonates.

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