Significant reduction of serum homocysteine level and oral symptoms after different vitamin-supplement treatments in patients with burning mouth syndrome

Authors

  • Andy Sun,

    1. Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan
    2. School of Dentistry, National Taiwan University, Taipei, Taiwan
    3. Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
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  • Hung-Pin Lin,

    1. Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan
    2. School of Dentistry, National Taiwan University, Taipei, Taiwan
    3. Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
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  • Yi-Ping Wang,

    1. Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan
    2. School of Dentistry, National Taiwan University, Taipei, Taiwan
    3. Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
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  • Hsin-Ming Chen,

    1. School of Dentistry, National Taiwan University, Taipei, Taiwan
    2. Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    3. Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan
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  • Shih-Jung Cheng,

    1. School of Dentistry, National Taiwan University, Taipei, Taiwan
    2. Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
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  • Chun-Pin Chiang

    Corresponding author
    1. School of Dentistry, National Taiwan University, Taipei, Taiwan
    2. Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    3. Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan
    • Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan
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Correspondence: Chun-Pin Chiang, Department of Dentistry, National Taiwan University Hospital, No. 1, Chang-Te Street, Taipei 10048, Taiwan. Tel: +886 2 23123456×66855, fax: +886 2 23893853. E-mail: cpchiang@ntu.edu.tw

Abstract

Background

Serum homocysteine level is a biomarker of cardiovascular disease.

Methods

In this study, 399 primary and secondary burning mouth syndrome (BMS) patients without or with hematinic deficiencies were treated with vitamin BC capsules plus none, one, or two deficient hematinics depending on the corresponding deficiency statuses of the patients. One hundred and seventy-seven patients showed complete remission of all oral symptoms after treatment. The blood homocysteine, vitamin B12, folic acid, iron, and hemoglobin concentrations at baseline and after treatment till all oral symptoms had disappeared in these 177 complete-response BMS patients were measured and compared by paired t-test.

Results

For BMS patients with concomitant deficiencies of vitamin B12 only (n = 48), folic acid only (n = 12), vitamin B12 plus folic acid (n = 9), or vitamin B12 plus iron (n = 15), supplementations with vitamin BC capsules plus corresponding deficient hematinics could significantly reduce the abnormally high serum homocysteine levels to normal levels after a mean treatment period of 5.4–8.2 months (all P-values < 0.01). For BMS patients without definite hematinic deficiencies (n = 62), supplementation with vitamin BC capsules only could also significantly decrease the relatively higher homocysteine levels to significantly lower levels after a mean treatment period of 10.2 months (< 0.001).

Conclusion

Specific supplementations with vitamin BC capsules plus none or corresponding deficient vitamin B12 and/or folic acid can reduce the abnormally high serum homocysteine levels to normal levels in BMS patients without or with deficiencies of corresponding hematinics.

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