Inflammatory factors gene polymorphism in recurrent oral ulceration
Article first published online: 14 FEB 2013
© 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd
Journal of Oral Pathology & Medicine
Volume 42, Issue 7, pages 528–534, August 2013
How to Cite
J Oral Pathol Med (2013) 42: 528−534
- Issue published online: 23 JUL 2013
- Article first published online: 14 FEB 2013
- Manuscript Accepted: 3 JAN 2013
- National Foundation of Natural Science of China. Grant Number: 30600268
- Natural Science Foundation. Grant Number: 2005C2-15
- National Natural Science Foundation of China. Grant Number: 30901359
- Key Project Foundation. Grant Number: 2010K01-194
- ShaanXi Science & Technology Commission
- gene polymorphisms;
- inflammatory factors;
- recurrent oral ulceration;
Some inflammatory factors play an important role in recurrent oral ulceration (ROU). The genetics mechanism of expression level of inflammatory factors is not clear in ROU, but from genetics the expression level of inflammatory factors at least partly depend on the gene polymorphisms. Therfore, we decided to investigate inflammatory factors gene polymorphism and its association with the susceptibility of recurrent oral ulceration in Chinese.
Genomic DNA was obtained from 42 subjects with recurrent oral ulceration, 86 subjects of healthy control individuals.Genotypes and alleles of 10 genes and 17 polymorphisms sites were analyzed by Mass-ARRAY Analyzer method. Then, the differences in distribution of each genotype and allele were compared.
The statistical differences in distribution of TNF-α (rs1800629 and rs1800630) genotype and allele were observed among the groups with recurrent oral ulceration and healthy control individuals (P < 0.01), while VEGFA (rs1570360, rs833061, and rs2010963), EGF (rs4444903), TNF (rs361525), IL10 (rs1800896, rs1800872), IL2 (rs2069762), IL4 (rs2243250), Fas (rs1800682, rs2234767), IL12A (rs2243115, rs568408), IL12B (rs3212227), and IFNG (rs2430561) showed no statistical differences of genotype and allele in controls as compared to those in patients.
This study suggests that the TNF-α (rs1800629 and rs1800630) genotype is an indicator for the susceptibility of recurrent oral ulceration.