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Inflammatory factors gene polymorphism in recurrent oral ulceration

Authors

  • Mao Sun,

    1. Center for DNA Typing, Fourth Military Medical University, Xi'an, China
    2. Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, China
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  • Shan-Min Fu,

    1. Department of Orthodontics, Fourth Military Medical University, Xi'an, China
    2. School of Stomatology, Fourth Military Medical University, Xi'an, China
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  • Guang-Ying Dong,

    1. Department of Periodontics and Oral Medicine, Fourth Military Medical University, Xi'an, China
    2. School of Stomatology, Fourth Military Medical University, Xi'an, China
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  • Dan Wu,

    1. Center for DNA Typing, Fourth Military Medical University, Xi'an, China
    2. Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, China
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  • Guo-Xia Wang,

    1. Center for DNA Typing, Fourth Military Medical University, Xi'an, China
    2. Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, China
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  • Yuanming Wu

    Corresponding author
    1. Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, China
    • Center for DNA Typing, Fourth Military Medical University, Xi'an, China
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Correspondence: Yuanming Wu, The Fourth Military Medical University, 169 Changle west Road, Xi'an 710032 Shanxi Province, China. Tel/Fax: +86 029 84774978. E-mail: wuym@fmmu.edu.cn

Abstract

Background

Some inflammatory factors play an important role in recurrent oral ulceration (ROU). The genetics mechanism of expression level of inflammatory factors is not clear in ROU, but from genetics the expression level of inflammatory factors at least partly depend on the gene polymorphisms. Therfore, we decided to investigate inflammatory factors gene polymorphism and its association with the susceptibility of recurrent oral ulceration in Chinese.

Methods

Genomic DNA was obtained from 42 subjects with recurrent oral ulceration, 86 subjects of healthy control individuals.Genotypes and alleles of 10 genes and 17 polymorphisms sites were analyzed by Mass-ARRAY Analyzer method. Then, the differences in distribution of each genotype and allele were compared.

Results

The statistical differences in distribution of TNF-α (rs1800629 and rs1800630) genotype and allele were observed among the groups with recurrent oral ulceration and healthy control individuals (P < 0.01), while VEGFA (rs1570360, rs833061, and rs2010963), EGF (rs4444903), TNF (rs361525), IL10 (rs1800896, rs1800872), IL2 (rs2069762), IL4 (rs2243250), Fas (rs1800682, rs2234767), IL12A (rs2243115, rs568408), IL12B (rs3212227), and IFNG (rs2430561) showed no statistical differences of genotype and allele in controls as compared to those in patients.

Conclusions

This study suggests that the TNF-α (rs1800629 and rs1800630) genotype is an indicator for the susceptibility of recurrent oral ulceration.

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