Disseminated tuberculosis and tuberculous meningitis in Australian-born children; case reports and review of current epidemiology and management

Authors

  • Benjamin B Smith,

    Corresponding author
    • Discipline of Paediatrics and Child Health, University of Sydney, Sydney, New South Wales, Australia
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  • Briony J Hazelton,

    1. Department of Microbiology and Infectious Diseases, The Children's Hospital at Westmead, Sydney, New South Wales, Australia
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  • Anita E Heywood,

    1. School of Public Health and Community Medicine, University of New South Wales, Sydney, New South Wales, Australia
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  • Thomas L Snelling,

    1. Department of Immunology and Infectious Diseases, Sydney Children's Hospital, Sydney, New South Wales, Australia
    2. National Centre for Immunisation Research and Surveillance, Sydney, New South Wales, Australia
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  • Kenneth M Peacock,

    1. Department of General Medicine, The Children's Hospital at Westmead, Sydney, New South Wales, Australia
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  • Kristine K Macartney

    1. Discipline of Paediatrics and Child Health, University of Sydney, Sydney, New South Wales, Australia
    2. Department of Microbiology and Infectious Diseases, The Children's Hospital at Westmead, Sydney, New South Wales, Australia
    3. Department of General Medicine, The Children's Hospital at Westmead, Sydney, New South Wales, Australia
    4. National Centre for Immunisation Research and Surveillance, Sydney, New South Wales, Australia
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  • Declaration of conflict of interest: None declared.

Correspondence: Dr Benjamin B Smith, Department of Microbiology and Infectious Diseases, The Children's Hospital at Westmead, Locked Bag 4001, Westmead NSW 2145, Australia. Fax: 02 9845 1418; email: bens@chw.edu.au

Abstract

Abstract

We present two cases of tuberculous meningitis in Australian-born children. We review the current literature surrounding management of paediatric tuberculosis and disseminated disease, emphasising the importance of prompt diagnosis and intervention. We discuss the epidemiology of tuberculosis in the Australian paediatric population and highlight the sentinel role of childhood infection in public health surveillance.

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