Get access

Rapidly evolving hypopituitarism in a boy with multiple autoimmune disorders

Authors

  • Ganesh Jevalikar,

    1. Department of Endocrinology and Diabetes, The Royal Children's Hospital, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia
    Search for more papers by this author
  • Sze Choong Wong,

    1. Department of Endocrinology and Diabetes, The Royal Children's Hospital, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia
    Search for more papers by this author
  • Margaret Zacharin

    Corresponding author
    • Department of Endocrinology and Diabetes, The Royal Children's Hospital, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia
    Search for more papers by this author

  • Conflict of interest: None declared.

Correspondence: Associate Professor Margaret Zacharin, Department of Endocrinology and Diabetes, Royal Children's Hospital, Flemington Road, Parkville, Vic. 3052, Australia. Fax: +613 9347 7763; email: margaret.zacharin@rch.org.au

Abstract

A 10-year-old boy with acute onset cranial diabetes insipidus and multiple autoimmune disorders had evolving panhypopituitarism, thought to be due to autoimmune hypophysitis. Over 18 months, a dramatic clinical course with progressive hypopituitarism and development of type 1 diabetes mellitus was evident. Serial brain imaging showed changes suggestive of germinoma.

Get access to the full text of this article

Ancillary