Conflict of interest: The authors report no relevant conflicts of interest nor have they received any relevant financial support.
Paediatric community-associated Staphylococcus aureus: A retrospective cohort study
Article first published online: 30 MAY 2013
© 2013 The Authors. Journal of Paediatrics and Child Health © 2013 Paediatrics and Child Health Division (Royal Australasian College of Physicians)
Journal of Paediatrics and Child Health
Volume 49, Issue 9, pages 754–759, September 2013
How to Cite
Britton, P. N. and Andresen, D. N. (2013), Paediatric community-associated Staphylococcus aureus: A retrospective cohort study. Journal of Paediatrics and Child Health, 49: 754–759. doi: 10.1111/jpc.12255
- Issue published online: 5 SEP 2013
- Article first published online: 30 MAY 2013
- Manuscript Accepted: 14 JAN 2013
- general paediatrics;
- infectious diseases;
- skin and soft tissue infection;
- Staphylococcus aureus
We aimed to characterise the demographic and clinical features of paediatric community-associated Staphylococcus aureus (CA-SA) infection. We aimed to identify factors associated with methicillin-resistant S. aureus (MRSA) infection evident at the point of care with the potential to guide antibiotic choice.
A retrospective chart review in 2008 of CA-SA infections at the Children's Hospital at Westmead (CHW), a 300-bed tertiary paediatric hospital in western Sydney, Australia. We calculate rates of MRSA and perform univariate and multivariate analysis for predictors of MRSA.
Of 431 patients with CA-SA infections, 19.3% were MRSA. In univariate analysis, MRSA was predicted by age greater than 1 year, Aboriginal race, rural/regional residence, previous history of skin and soft tissue infection (SSTI) or a family history of SSTI, at least 48 h of antibiotics active against methicillin-sensitive S. aureus (MSSA), invasive infection and abscess formation. In a multivariate analysis factors that independently predicted MRSA in the entire cohort, and in the non-invasive subgroup included abscess formation, a family history of staphylococcal infection or SSTI, Aboriginal ethnicity, at least 48 h of anti-MSSA antibiotics at presentation, presentation during spring and age greater than 1 year.
One fifth of CA-SA infections at our tertiary paediatric hospital in 2008 were MRSA. Several clinical and demographic factors evident at the point of care were highly significant predictors of CA-MRSA infection.