Conflict of interest: None declared.
Genetic and clinical contributions to cerebral palsy: A multi-variable analysis
Article first published online: 11 JUN 2013
© 2013 The Authors. Journal of Paediatrics and Child Health © 2013 Paediatrics and Child Health Division (Royal Australasian College of Physicians)
Journal of Paediatrics and Child Health
Volume 49, Issue 7, pages 575–581, July 2013
How to Cite
O'Callaghan, M. E., MacLennan, A. H., Gibson, C. S., McMichael, G. L., Haan, E. A., Broadbent, J. L., Baghurst, P. A., Goldwater, P. N., Dekker, G. A. and Australian Collaborative Cerebral Palsy Research Group (2013), Genetic and clinical contributions to cerebral palsy: A multi-variable analysis. Journal of Paediatrics and Child Health, 49: 575–581. doi: 10.1111/jpc.12279
- Issue published online: 11 JUL 2013
- Article first published online: 11 JUN 2013
- Manuscript Accepted: 30 NOV 2012
- National Health and Medical Research Council
- The Research Foundation of Cerebral Palsy Alliance
- case control;
- cerebral palsy;
This study aims to examine single nucleotide polymorphism (SNP) associations with cerebral palsy in a multi-variable analysis adjusting for potential clinical confounders and to assess SNP–SNP and SNP–maternal infection interactions as contributors to cerebral palsy.
A case control study including 587 children with cerebral palsy and 1154 control children without cerebral palsy. Thirty-nine candidate SNPs were genotyped in both mother and child. Data linkage to perinatal notes and cerebral palsy registers was performed with a supplementary maternal pregnancy questionnaire. History of known maternal infection during pregnancy was extracted from perinatal databases.
Both maternal and fetal carriage of inducible nitric oxide synthase SNP rs1137933 were significantly negatively associated with cerebral palsy in infants born at less than 32 weeks gestation after adjustment for potential clinical confounders and correction for multiple testing (odds ratio 0.55, 95% confidence interval 0.38–0.79; odds ratio 0.57, 95% confidence interval 0.4–0.82, respectively). Analysis did not show any statistically significant SNP–SNP or SNP–maternal infection interactions after correction for multiple testing.
Maternal and child inducible nitric oxide synthase SNPs are associated with reduced risk of cerebral palsy in infants born very preterm. There was no evidence for statistically significant SNP–SNP or SNP–maternal infection interactions as modulators of cerebral palsy risk.