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Genetic and clinical contributions to cerebral palsy: A multi-variable analysis

Authors

  • Michael E O'Callaghan,

    Corresponding author
    • Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, Robinson Institute, Adelaide, South Australia, Australia
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  • Alastair H MacLennan,

    1. Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, Robinson Institute, Adelaide, South Australia, Australia
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  • Catherine S Gibson,

    1. Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, Robinson Institute, Adelaide, South Australia, Australia
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  • Gai L McMichael,

    1. Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, Robinson Institute, Adelaide, South Australia, Australia
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  • Eric A Haan,

    1. Discipline of Paediatrics, School of Paediatrics and Reproductive Health, The University of Adelaide, Adelaide, South Australia, Australia
    2. SA Clinical Genetics Service, SA Pathology at Women's and Children's Hospital, Adelaide, South Australia, Australia
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  • Jessica L Broadbent,

    1. Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, Robinson Institute, Adelaide, South Australia, Australia
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  • Peter A Baghurst,

    1. Discipline of Paediatrics, School of Paediatrics and Reproductive Health, The University of Adelaide, Adelaide, South Australia, Australia
    2. Public Health Research Unit, Women's and Children's Hospital, Adelaide, South Australia, Australia
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  • Paul N Goldwater,

    1. Discipline of Paediatrics, School of Paediatrics and Reproductive Health, The University of Adelaide, Adelaide, South Australia, Australia
    2. Department of Microbiology and Infectious Diseases, SA Pathology at Women's and Children's Hospital, Adelaide, South Australia, Australia
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  • Gustaaf A Dekker,

    1. Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, Robinson Institute, Adelaide, South Australia, Australia
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  • and for the Australian Collaborative Cerebral Palsy Research Group


  • Conflict of interest: None declared.

Correspondence: Dr Michael E O'Callaghan, Robinson Institute, Discipline of Obstetrics and Gynaecology, Level 3, Norwich Centre, 55 King William Road, North Adelaide, SA 5006, Australia. Fax: +61 8 8313 1333; email: michael.ocallaghan@adelaide.edu.au

Abstract

Aim

This study aims to examine single nucleotide polymorphism (SNP) associations with cerebral palsy in a multi-variable analysis adjusting for potential clinical confounders and to assess SNP–SNP and SNP–maternal infection interactions as contributors to cerebral palsy.

Methods

A case control study including 587 children with cerebral palsy and 1154 control children without cerebral palsy. Thirty-nine candidate SNPs were genotyped in both mother and child. Data linkage to perinatal notes and cerebral palsy registers was performed with a supplementary maternal pregnancy questionnaire. History of known maternal infection during pregnancy was extracted from perinatal databases.

Results

Both maternal and fetal carriage of inducible nitric oxide synthase SNP rs1137933 were significantly negatively associated with cerebral palsy in infants born at less than 32 weeks gestation after adjustment for potential clinical confounders and correction for multiple testing (odds ratio 0.55, 95% confidence interval 0.38–0.79; odds ratio 0.57, 95% confidence interval 0.4–0.82, respectively). Analysis did not show any statistically significant SNP–SNP or SNP–maternal infection interactions after correction for multiple testing.

Conclusions

Maternal and child inducible nitric oxide synthase SNPs are associated with reduced risk of cerebral palsy in infants born very preterm. There was no evidence for statistically significant SNP–SNP or SNP–maternal infection interactions as modulators of cerebral palsy risk.

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