Conflict of interest: The authors have no conflict of interest.
Assessment of atherosclerosis in obese adolescents: Positive correlation of mean platelet volume and carotid intima media thickness
Article first published online: 19 JUN 2013
© 2013 The Authors. Journal of Paediatrics and Child Health © 2013 Paediatrics and Child Health Division (Royal Australasian College of Physicians)
Journal of Paediatrics and Child Health
Volume 49, Issue 11, pages 963–968, November 2013
How to Cite
Arslan, N., Makay, B., Hızlı, Ş., Koçyiğit, A., Demircioğlu, F., Tuncel, A. S. and Çakmakçı, H. (2013), Assessment of atherosclerosis in obese adolescents: Positive correlation of mean platelet volume and carotid intima media thickness. Journal of Paediatrics and Child Health, 49: 963–968. doi: 10.1111/jpc.12301
- Issue published online: 20 NOV 2013
- Article first published online: 19 JUN 2013
- Manuscript Accepted: 28 APR 2013
- carotid intima media thickness;
- mean platelet volume;
- non-alcoholic fatty liver disease;
This study aims to assess the correlation of mean platelet volume (MPV) and common carotid artery (CCA) thickness in a population of obese adolescents.
Sixty-eight patients and 23 controls were enrolled. Anthropometric measurements, triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, alanine aminotransferase, aspartate aminotransferase, γ-glutamyl transpeptidase, hemoglobin, white blood cell count, platelet count, MPV and insulin resistance by homeostasis model of assessment of insulin resistance were investigated. Furthermore, CCA thickness was measured by high-resolution ultrasound.
MPV and the left CCA thickness were significantly higher in obese adolescents than the healthy controls. The association between MPV and left CCA was checked by linear regression analysis. MPV explained 19% of the variation in left CCA (P < 0.001). At multiple regression analysis, MPV maintained a positive association with the left CCA thickness (P = 0.002) independently of fatty liver grade, relative weight, total cholesterol and homeostasis model of assessment of insulin resistance.
MPV is significantly correlated with CCA thickness in obese adolescents.