Henoch–Schönlein purpura in children

Authors

  • Peter Trnka

    Corresponding author
    1. Queensland Child and Adolescent Renal Service, Royal Children's Hospital, Herston, Queensland, Australia
    • Correspondence: Dr. Peter Trnka, Queensland Child and Adolescent Renal Service, Royal Children's Hospital, Woolworths Building, 5th Floor, Herston Road, Herston, QLD, 4029, Australia. Fax: (07) 3636 5505; email: Peter_Trnka@health.qld.gov.au

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  • Conflict of interest: None.

Abstract

Henoch–Schönlein purpura is the most common systemic vasculitis of childhood. In the majority of children, the outcome of Henoch–Schönlein purpura is excellent with spontaneous resolution of symptoms and signs. However, a small subset of patients will develop long-term sequelae in the form of chronic kidney disease. While the clinical presentation and diagnosis of Henoch–Schönlein purpura is straightforward, treatment of Henoch–Schönlein purpura nephritis and long-term renal outcomes of more severely affected children are less certain. This review article gives a general overview of Henoch–Schönlein purpura with emphasis on recently published information, including the new classification of childhood vasculitis, insights into pathogenesis of Henoch–Schönlein purpura and a summary of various treatments of established Henoch–Schönlein purpura nephritis.

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