Henoch–Schönlein purpura in children


  • Peter Trnka

    Corresponding author
    1. Queensland Child and Adolescent Renal Service, Royal Children's Hospital, Herston, Queensland, Australia
    • Correspondence: Dr. Peter Trnka, Queensland Child and Adolescent Renal Service, Royal Children's Hospital, Woolworths Building, 5th Floor, Herston Road, Herston, QLD, 4029, Australia. Fax: (07) 3636 5505; email: Peter_Trnka@health.qld.gov.au

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  • Conflict of interest: None.


Henoch–Schönlein purpura is the most common systemic vasculitis of childhood. In the majority of children, the outcome of Henoch–Schönlein purpura is excellent with spontaneous resolution of symptoms and signs. However, a small subset of patients will develop long-term sequelae in the form of chronic kidney disease. While the clinical presentation and diagnosis of Henoch–Schönlein purpura is straightforward, treatment of Henoch–Schönlein purpura nephritis and long-term renal outcomes of more severely affected children are less certain. This review article gives a general overview of Henoch–Schönlein purpura with emphasis on recently published information, including the new classification of childhood vasculitis, insights into pathogenesis of Henoch–Schönlein purpura and a summary of various treatments of established Henoch–Schönlein purpura nephritis.