Conflict of interest: No conflicts of interest.
Acute encephalitis in children: Progress and priorities from an Australasian perspective
Article first published online: 22 JUN 2014
© 2014 The Authors. Journal of Paediatrics and Child Health © 2014 Paediatrics and Child Health Division (Royal Australasian College of Physicians)
Journal of Paediatrics and Child Health
Volume 51, Issue 2, pages 147–158, February 2015
How to Cite
Britton, P. N., Dale, R. C., Booy, R. and Jones, C. A. (2015), Acute encephalitis in children: Progress and priorities from an Australasian perspective. Journal of Paediatrics and Child Health, 51: 147–158. doi: 10.1111/jpc.12650
- Issue published online: 9 FEB 2015
- Article first published online: 22 JUN 2014
- Manuscript Accepted: 9 APR 2014
Encephalitis is a complex neurological syndrome caused by inflammation of the brain that occurs with highest incidence in children. It is challenging to diagnose and manage due to the variety of aetiologies and non-specific clinical presentations. We discuss the recent progress in clinical case definitions; review recent, large, prospective epidemiological studies; and describe aetiologies. We emphasise infectious causes relevant to children in Australasia but also consider emerging immune-mediated syndromes responsive to immune therapies. We identify priorities for future research in children, given the potential for climate change and international travel to influence the emergence of infectious agents in our region.