Conflict of interest: The authors declare no conflict of interest.
Oral vitamin B12 treatment is effective for children with nutritional vitamin B12 deficiency
Article first published online: 18 JUN 2014
© 2014 The Authors. Journal of Paediatrics and Child Health © 2014 Paediatrics and Child Health Division (Royal Australasian College of Physicians)
Journal of Paediatrics and Child Health
Volume 50, Issue 9, pages 721–725, September 2014
How to Cite
Bahadir, A., Reis, P. G. and Erduran, E. (2014), Oral vitamin B12 treatment is effective for children with nutritional vitamin B12 deficiency. Journal of Paediatrics and Child Health, 50: 721–725. doi: 10.1111/jpc.12652
- Issue published online: 25 AUG 2014
- Article first published online: 18 JUN 2014
- Manuscript Accepted: 13 MAR 2014
- vitamin B12
Despite being one of common preventable deficiency disorders, vitamin B12 (vit-B12) deficiency can lead to serious health problems both in children and adult. The familiar treatment through parenteral route for vit-B12 deficiency frequently leads to poor adherence, and adequate response to treatment has lead to interest in oral supplementation. This study investigates the efficacy of oral vit-B12 treatment in children with nutritional vit-B12 deficiency.
Forty-seven children (from 1 month to 17 years) with vit-B12 levels below 200 pg/mL were allocated either of two study groups: Group 1 (1–20 months) and Group 2 (6–17 years) which were subdivided according to the duration of treatment (Group 1A&2A: 4 months; Group 1B&2B: 8 months of 1000 μg oral vit-B12, every day for a week, every other day for 2 weeks, 2 days a week for 2 weeks, then once a week).
Vit-B12 levels among all groups were significantly restored following high oral vit-B12 doses (P = 0.013, P = 0.001), the regimen being more effective in Group1A and Group1B. Correlation analysis of serum vit-B12 levels and age at the end of treatment revealed a decreasing trend with the increasing patient age (corelation respectively −65.2%, P = 0.08; −35.4%; P = 0.25).
Data from this study indicate that oral vit-B12 (1000 μg) for 4 months is effective, giving clinicians more choice, for treatment of children with nutritional vit-B12 deficiency. However, despite this high dose, lower levels were achieved in older children indicating the necessity of dosage adjustment in accordance with body weight.