Dedication: This work is dedicated to Late Mr Brij Mohan Singh who did MS at NIPER, Hyderabad.
Curcumin potentiates the anti-arthritic effect of prednisolone in Freund's complete adjuvant-induced arthritic rats
Article first published online: 21 OCT 2013
© 2013 Royal Pharmaceutical Society
Journal of Pharmacy and Pharmacology
Volume 66, Issue 1, pages 133–144, January 2014
How to Cite
Kuncha, M., Naidu, V. G. M., Sahu, B. D., Gadepalli, S. G. and Sistla, R. (2014), Curcumin potentiates the anti-arthritic effect of prednisolone in Freund's complete adjuvant-induced arthritic rats. Journal of Pharmacy and Pharmacology, 66: 133–144. doi: 10.1111/jphp.12156
- Issue published online: 17 DEC 2013
- Article first published online: 21 OCT 2013
- Manuscript Accepted: 11 SEP 2013
- Manuscript Received: 25 APR 2013
- CSIR. Grant Number: CSC 0111
- FCA-induced arthritis;
- oxidative stress;
The present study was aimed at investigating the effect of curcumin in combination with prednisolone for the effective treatment of arthritis with reduced side effects when glucocorticoids therapy is indicated.
Arthritis was induced in wistar rats by subplantar injection of Freund's complete adjuvant, and animals were observed for the symptoms of arthritis during the period of 21 days. Combined treatment of curcumin with various doses of prednisolone (1.25, 2.5 and 5 mg/kg) was evaluated in order to ascertain the efficacy and toxicity induced by steroid.
Arthritic animals showed significant increase in tumour necrosis factor-α and IL-1β levels in paw tissue and IL-1β in serum. Combined therapy of curcumin with low doses of prednisolone showed pronounced beneficial effect on joint swelling, leucocyte count and biochemical parameters compared with prednisolone groups. Among the different doses used in the study, prednisolone at 1.25 mg/kg in combination with curcumin showed beneficial anti-arthritic activity and also reduced the steroid toxicity. This is evidenced by increase in body weight, low toxicity to immune organs, reduction in leucocyte count, increase in spleen anti-oxidant enzymes and potent inhibition of cytokines in combination group.
Therefore, combined treatment of curcumin with low doses of prednisolone may find therapeutic use in arthritis.