Synthesis of Aryl Aldimines and Their Activity against Fungi of Clinical Interest (pages 810–815)
Cleiton M. da Silva, Danielle L. da Silva, Cleide V.B. Martins, Maria A. de Resende, Esther S. Dias, Thais F.F. Magalhães, Letícia P. Rodrigues, Adão A. Sabino, Rosemeire B. Alves and Ângelo de Fátima
Version of Record online: 6 SEP 2011 | DOI: 10.1111/j.1747-0285.2011.01185.x
Six aryl aldimines were synthesized from the condensation of aromatic amines with benzaldehydes. The antifungal activities of synthesized compounds were evaluated against nineteen fungi strains that included Candida and Aspergillus species and Cryptococcus neoformans. The aryl aldimines 2-(benzylideneamino)phenol (3) and 4-(benzylideneamino)phenol (8) were the most active compounds against the fungi studied. Such compounds inhibited efficiently the metabolism of C. neoformans mature biofilm.