Synthesis of Lipophilic Genistein Derivatives and Their Regulation of IL-12 and TNF-α in Activated J774A.1 Cells (pages 347–352)
Sandra B. R. Castro, Celso O. R. Junior, Caio C. S. Alves, Alyria T. Dias, Lívia L. Alves, Luciano Mazzoccoli, Mateus T. Zoet, Sérgio A. Fernandes, Henrique C. Teixeira, Mauro V. Almeida and Ana Paula Ferreira
Article first published online: 19 JAN 2012 | DOI: 10.1111/j.1747-0285.2011.01296.x
This work describes the synthesis and evaluation of the effect of novel lipophilic genistein derivatives on IL-12, TNF-α and NO production by J774A.1 cells. The results show that the modification of genistein enables the generation of non-cytotoxic compounds with increased IL-12 inhibition. The NO production was notably inhibited by the monoester (2, 3) and monoether (6, 7) compounds in a dose-dependent manner.