p38β MAP Kinase as a Therapeutic Target for Pancreatic Cancer (pages 266–273)
Abhay Kumar Singh, Roshan Pandey, Kamaldeep Gill, Ratnakar Singh, Anoop Saraya, Shyam S. Chauhan, Savita Yadav, Sujoy Pal, Nidhi Singh and Sharmistha Dey
Version of Record online: 23 MAY 2012 | DOI: 10.1111/j.1747-0285.2012.01395.x
This study focused on development of P38β MAPK as a biological marker of pancreatic cancer, as this is an important component of intracellular signaling pathway that are activated in response to many extracellular stimuli leading to inflammatory response and eventually into cancer and was compared with the pancreatitic patients. In addition, we have designed and analysed the peptide inhibitor on the basis of the structure of ATP binding site of P38β and the known inhibitors.