jpy12028-sup-0001-FigS1.pdfPDF document314KFigure S1. Distribution of summed contig lengths for all contigs that had top BLASTx hits to phage sequences. These 136 contigs from the PoL cell 1 genome assembly encoded 415 predicted proteins.
jpy12028-sup-0002-FigS2.pdfPDF document576KFigure S2. Maximum likelihood (RAxML) tree of flavin-dependent (FAD) thymidylate synthase using a protein encoded on contig 5. RAxML bootstrap values for the tree is shown when ≥50%. Cyanophage are in red text, Cyanobacteria are in blue text, and the contig 5 protein is in magenta text.
jpy12028-sup-0003-FigS3.pdfPDF document388KFigure S3. Explanation of network analysis of PoL cell 1 cyanophage proteins. Predicted proteins from PoL cell 1 (red nodes) and other cyanophages (other nodes) were connected when they shared a significant sequence relationship in pairwise comparisons. These relationships defined operational gene families (connected subgraphs). Using this approach, we screened subgraphs to identify gene families in which at least one protein from PoL cell 1 was directly connected (hence highly similar) to at least one protein from 17 other cyanophage genomes (blue nodes). Six topological properties were computed in each selected subgraph for both the red and blue nodes. Each gene family was described by a vector of 6 Boolean values (i.e., one for each topological property). When a pair of directly connected red and blue nodes showed the same topological property, the value of this topological property was set to TRUE in the vector. In contrast, if there was no pair of linked red and blue nodes that showed the same value for a topological property, the vector value was set to FALSE. These topological properties are indicated here with examples of their corresponding values (in brackets).
jpy12028-sup-0004-TableS1.pdfPDF document45KTable S1. List of contigs that putatively derive from phage PoL_MC2 (green field) and the four contigs that putative derive from an unknown phage putatively related to cyanophage (red field) that was identified in fosmid data from the Mediterranean Sea deep chlorophyll maximum (MedDCM).
jpy12028-sup-0005-TableS2.pdfPDF document75KTable S2. All proteins identified in the PoL cell 1 assembly that have top hits to phage genomes.
jpy12028-sup-0006-TableS3.pdfPDF document58KTable S3. Proteins identified in the PoL cell 1 assembly that have top hits to cyanophage genomes.
jpy12028-sup-0007-TableS4.pdfPDF document57KTable S4. Proteins identified in the PoL cell 1 assembly that have top hits to fosmid-encoded proteins from the Mediterranean Sea deep chlorophyll maximum study (Ghai et al. 2010).

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