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Radical Prostatectomy, Sparing of the Seminal Vesicles, and Painful Orgasm

Authors

  • Andrea Mogorovich MD,

    1. Department of Surgery, Section of Urology, University of Pisa, Pisa, Italy
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    • Authors contributed equally.
  • Andreas E. Nilsson MD,

    1. Department of Molecular Medicine and Surgery, Section of Urology, Karolinska Institutet, Stockholm, Sweden
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    • Authors contributed equally.
  • Stavros I. Tyritzis MD, PhD, FEBU,

    Corresponding author
    1. Department of Urology, Athens University Medical School, Laiko Hospital, Athens, Greece
    • Department of Molecular Medicine and Surgery, Section of Urology, Karolinska Institutet, Stockholm, Sweden
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    • Authors contributed equally.
  • Stefan Carlsson MD, PhD,

    1. Department of Molecular Medicine and Surgery, Section of Urology, Karolinska Institutet, Stockholm, Sweden
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  • Martin Jonsson MD,

    1. Department of Molecular Medicine and Surgery, Section of Urology, Karolinska Institutet, Stockholm, Sweden
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  • Leif Haendler MD,

    1. Department of Molecular Medicine and Surgery, Section of Urology, Karolinska Institutet, Stockholm, Sweden
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  • Tommy Nyberg MSc,

    1. Department of Oncology and Pathology, Section of Clinical Cancer Epidemiology, Karolinska Institutet, Stockholm, Sweden
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  • Gunnar Steineck MD, PhD,

    1. Department of Oncology and Pathology, Section of Clinical Cancer Epidemiology, Karolinska Institutet, Stockholm, Sweden
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    • Authors contributed equally.
  • N. Peter Wiklund MD, PhD

    1. Department of Molecular Medicine and Surgery, Section of Urology, Karolinska Institutet, Stockholm, Sweden
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Corresponding Author: Stavros I. Tyritzis, MD, PhD, FEBU, Department of Molecular Medicine and Surgery, Section of Urology, Karolinska Institutet, Solna 17176, Sweden. Tel: +46-8-517-745-41; Fax: +46-8-517-735-99; E-mail: styritzis@gmail.com

Abstract

Introduction

Erectile dysfunction has been widely investigated as the major factor responsible for sexual bother in patients after radical prostatectomy (RP); painful orgasm (PO) is one element of this bother, but little is known about its prevalence and its effects on sexual health.

Aim

This study aims to investigate the prevalence of PO and to identify potential risk factors.

Main Outcome Measures

A total of 1,411 consecutive patients underwent open (radical retropubic prostatectomy) or robot-assisted laparoscopic RP between 2002 and 2006. The patients were asked to complete a study-specific questionnaire.

Methods

Of a total of 145 questions, 5 dealt with the orgasmic characteristics. The questionnaire was also administered to a comparison group of 442 persons, matched for age and area of residency.

Results

The response rate was 91% (1,288 patients). A total of 143 (11%) patients reported PO. Among the 834 men being able to have an orgasm, the prevalence was 18% vs. 6% in the comparison group (relative risk [RR] 2.8, 95% confidence interval [CI] 1.7–4.5). When analyzed as independent variables, bilateral seminal vesicle (SV)-sparing approach (RR 2.33, 95% CI 1.0–5.3, P = 0.045) and age <60 years were significantly related to the presence of PO (95% CI 0.5–0.9, P = 0.019). After adjustment for age, bilateral SV-sparing still remained a significant predictor for occurrence of PO.

Conclusions

We found that PO occurs significantly more often in patients undergoing bilateral SV-sparing RP when compared with age-matched comparison population.

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