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Comparing Effects of Low- and High-Volume Moderate-Intensity Exercise on Sexual Function and Testosterone in Obese Men

Authors


  • ClinicalTrials.gov ID: NTC01554735.

Corresponding Author: Joan Khoo, MRCP, Department of Endocrinology, Changi General Hospital, 2 Simei St 3, Singapore 529889, Singapore. Tel: +65 68503807; Fax: +65 67816202; E-mail: joan_khoo@cgh.com.sg

Abstract

Introduction

Obesity and inactivity are associated with erectile dysfunction and hypogonadism.

Aim

To compare the effects of low volume (LV) and high volume (HV) of moderate-intensity exercise on sexual function, testosterone, lower urinary tract symptoms (LUTS), endothelial function, and quality of life (QoL) in obese men.

Main Outcome Measures

Weight, waist circumference (WC), body composition, International Index of Erectile Function 5-item (IIEF-5), International Prostate Symptom Scale (IPSS) (for LUTS), and 36-item Short Form Survey version 2 Instrument (SF-36) (for QoL) scores, plasma testosterone, sex-hormone binding globulin, glucose, insulin and lipids, and endothelial function (by Reactive Hyperaemia Index [RHI] using finger plethysmography) were measured at baseline and 24 weeks.

Methods

Ninety abdominally obese (body mass index > 27.5 kg/m2, WC > 90 cm), sedentary (exercise ∼80 minutes/week) Asian men (mean age 43.6 years, range 30–60) were prescribed a diet to reduce daily intake by ∼400 kcal below calculated requirement and randomized to perform moderate-intensity exercise of LV (<150 minutes/week) or HV (200–300 minutes/week) (n = 45 each) for 24 weeks. Seventy-five men (83.3%) completed the study.

Results

Weekly exercise volume was significantly greater in the HV (236 ± 9 minutes) than the LV (105 ± 9 minutes) group. The HV group had significantly greater increases in IIEF-5 score (2.6 ± 0.5 points) and testosterone (2.06 ± 0.46 nmol/L) and reductions in weight (−5.9 ± 0.7 kg, −6.2%), WC (−4.9 ± 0.8 cm, −4.9%), and fat mass (−4.7 ± 1.0 kg, −14.5%) than the LV group (−2.9 ± 0.7 kg, −3.0%; −2.7 ± 0.7 cm, −2.5%; −1.1 ± 0.8 kg, −3.2%; 0.79 ± 0.46 nmol/L; and 1.8 ± 0.5 points). Improvements in IPSS and SF-36 scores, and RHI, were similar.

Conclusions

Moderate-intensity HV aerobic exercise > 200 minutes/week produces greater improvements in sexual function, testosterone, weight, WC, and fat mass than smaller exercise volume. Khoo J, Tian H-H, Tan B, Chew K, Ng C-S, Leong D, Teo RC-C, and Chen RY-T. Comparing effects of low- and high-volume moderate-intensity exercise on sexual function and testosterone in obese men. J Sex Med **;**:**–**.

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