BPH/LUTS and ED: Common Pharmacological Pathways for a Common Treatment
Article first published online: 22 JUL 2013
© 2013 International Society for Sexual Medicine
The Journal of Sexual Medicine
Volume 10, Issue 10, pages 2382–2393, October 2013
How to Cite
Fusco, F., D'Anzeo, G., Sessa, A., Pace, G., Rossi, A., Capece, M. and d'Emmanuele di Villa Bianca, R. (2013), BPH/LUTS and ED: Common Pharmacological Pathways for a Common Treatment. Journal of Sexual Medicine, 10: 2382–2393. doi: 10.1111/jsm.12261
- Issue published online: 7 OCT 2013
- Article first published online: 22 JUL 2013
- Eli Lilly Italy
- Phosphodiesterase Type 5 Treatments
Introduction and Aim
This article reviews the current literature on common physiopathogenetic factors and pharmacological pathways of lower urinary tract symptoms (LUTS) and erectile dysfunction (ED) in men and their implications for diagnosis and treatment.
Main Outcome Measures and Methods
A literature search was conducted to identify original articles, reviews, editorials, and international scientific congress abstracts by combining the following terms: lower urinary tract symptoms, erectile dysfunction and phosphodiesterase type 5 inhibitors (and their abbreviations LUTS, ED and PDE5-Is).
We identified manuscripts presenting: (i) The existence of several newly discovered common pathophysiological mechanisms of LUTS and ED indicating that PDE5-Is might represent an alternative to current treatments of men with LUTS (e.g., α1-adrenergic blockers and 5α-reductase inhibitors); (ii) Randomized controlled clinical trials have shown that treatment with PDE5-Is is associated with improvements in both LUTS and ED in men with significant problems in both areas.
The presence of common pathophysiological mechanisms between LUTS and ED seems well recognized and needs further exploration. Further comparisons between different PDE5-Is would be useful to determine the most appropriate regimen and their efficacy to safety ratio. Fusco F, D'Anzeo G, Sessa A, Pace G, Rossi A, Capece M, and d'Emmanuele di Villa Bianca R. BPH/LUTS and ED: Common pharmacological pathways for a common treatment. J Sex Med 2013;10:2382–2393.