ORIGINAL RESEARCH–ERECTILE DYSFUNCTION
Weaker Masturbatory Erection May Be a Sign of Early Cardiovascular Risk Associated with Erectile Dysfunction in Young Men Without Sexual Intercourse
Article first published online: 3 MAR 2014
© 2014 International Society for Sexual Medicine
The Journal of Sexual Medicine
Volume 11, Issue 6, pages 1519–1526, June 2014
How to Cite
Huang, Y.-P., Chen, B., Yao, F.-J., Chen, S.-F., Ouyang, B., Deng, C.-H. and Huang, Y.-R. (2014), Weaker Masturbatory Erection May Be a Sign of Early Cardiovascular Risk Associated with Erectile Dysfunction in Young Men Without Sexual Intercourse. Journal of Sexual Medicine, 11: 1519–1526. doi: 10.1111/jsm.12460
- Issue published online: 6 JUN 2014
- Article first published online: 3 MAR 2014
- National Natural Science Foundation of China. Grant Numbers: 81270741, 81270696
- Erectile Dysfunction;
- Weaker Masturbatory Erection;
- Cardiovascular Risk;
- Young Men;
- No Sexual Intercourse;
- Early Cardiovascular Evaluation
Although increasing evidences emphasize the importance of early cardiovascular evaluation in men with erectile dysfunction (ED) of unexplained aetiology, impaired masturbation-induced erections in young men are usually overlooked and habitually presumed to be psychological origin.
To evaluate the young men presenting weaker masturbatory erection with no sexual intercourse (WME-NS) and verify if this cohort have early cardiovascular risks associated with ED.
Male subjects aged 18–40 years with WME-NS were screened by analyzing detailed sexual intercourse and masturbatory history. The age-matched ED and non-ED population were identified by using International Index of Erectile Function-5 (IIEF-5). All subjects with acute and/or chronic diseases (including diagnosed hypertension and diabetes) and long-term pharmacotherapy were excluded. Nocturnal penile tumescence and rigidity (NPTR), systemic vascular parameters and biochemical indicators related to metabolism were assessed.
Main Outcome Measures
Comparison analysis and logistic regression analysis were conducted among WME-NS, ED and non-ED population.
In total, 78 WME-NS cases (mean 28.99 ± 5.92 years), 179 ED cases (mean 30.69 ± 5.21 years) and 43 non-ED cases (mean 28.65 ± 4.30 years) were screened for analysis. Compared with non-ED group, WME-NS group had higher prevalence of early ED risk factors including endothelial dysfunction, insulin resistance, high level of glycosylated serum protein and abnormal NPTR. Multivariable-adjusted logistic regression analysis showed endothelia dysfunction (odds ratio: 8.83 vs. 17.11, both P < 0.001) was the independent risk factor for both WME-NS and ED.
Weaker masturbatory erection may be a sign of early cardiovascular risk associated with ED in young men without sexual intercourse. More studies are warranted to elucidate the clinical benefits by targeting these formulated strategies. Huang Y-P, Chen B, Yao F-J, Chen S-F, Ouyang B, Deng C-H, and Huang Y-R. Weaker masturbatory erection may be a sign of early cardiovascular risk associated with erectile dysfunction in young men without sexual intercourse. J Sex Med 2014;11:1519–1526.