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Weaker Masturbatory Erection May Be a Sign of Early Cardiovascular Risk Associated with Erectile Dysfunction in Young Men Without Sexual Intercourse

Authors

  • Yan-Ping Huang MD, PhD,

    1. Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Andrology, Shanghai, China
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  • Bin Chen MD, PhD,

    Corresponding author
    1. Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Andrology, Shanghai, China
    • Corresponding Author: Bin Chen, MD, PhD, Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Andrology, No. 145, Shandong Rd. Shanghai 200001, China. Tel: (+86)-21-63261981; Fax: (+86)-21-63111100; E-mail: dr_binchen@126.com

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  • Feng-Juan Yao MD,

    1. Department of Ultrasound, The First Hospital Affiliated Sun Yat-Sen University, Guangzhou, China
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  • Sheng-Fu Chen MD,

    1. Department of Urology, The First Hospital Affiliated Sun Yat-Sen University, Guangzhou, China
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  • Bin Ouyang MD,

    1. Department of Urology, The First Hospital Affiliated Sun Yat-Sen University, Guangzhou, China
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  • Chun-Hua Deng MD, PhD,

    1. Department of Urology, The First Hospital Affiliated Sun Yat-Sen University, Guangzhou, China
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  • Yi-Ran Huang MD, PhD

    1. Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Andrology, Shanghai, China
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Abstract

Introduction

Although increasing evidences emphasize the importance of early cardiovascular evaluation in men with erectile dysfunction (ED) of unexplained aetiology, impaired masturbation-induced erections in young men are usually overlooked and habitually presumed to be psychological origin.

Aims

To evaluate the young men presenting weaker masturbatory erection with no sexual intercourse (WME-NS) and verify if this cohort have early cardiovascular risks associated with ED.

Methods

Male subjects aged 18–40 years with WME-NS were screened by analyzing detailed sexual intercourse and masturbatory history. The age-matched ED and non-ED population were identified by using International Index of Erectile Function-5 (IIEF-5). All subjects with acute and/or chronic diseases (including diagnosed hypertension and diabetes) and long-term pharmacotherapy were excluded. Nocturnal penile tumescence and rigidity (NPTR), systemic vascular parameters and biochemical indicators related to metabolism were assessed.

Main Outcome Measures

Comparison analysis and logistic regression analysis were conducted among WME-NS, ED and non-ED population.

Results

In total, 78 WME-NS cases (mean 28.99 ± 5.92 years), 179 ED cases (mean 30.69 ± 5.21 years) and 43 non-ED cases (mean 28.65 ± 4.30 years) were screened for analysis. Compared with non-ED group, WME-NS group had higher prevalence of early ED risk factors including endothelial dysfunction, insulin resistance, high level of glycosylated serum protein and abnormal NPTR. Multivariable-adjusted logistic regression analysis showed endothelia dysfunction (odds ratio: 8.83 vs. 17.11, both P < 0.001) was the independent risk factor for both WME-NS and ED.

Conclusions

Weaker masturbatory erection may be a sign of early cardiovascular risk associated with ED in young men without sexual intercourse. More studies are warranted to elucidate the clinical benefits by targeting these formulated strategies. Huang Y-P, Chen B, Yao F-J, Chen S-F, Ouyang B, Deng C-H, and Huang Y-R. Weaker masturbatory erection may be a sign of early cardiovascular risk associated with erectile dysfunction in young men without sexual intercourse. J Sex Med 2014;11:1519–1526.

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