Serum Uric Acid as a Risk Predictor for Erectile Dysfunction

Authors

  • Sepehr Salem MD,

    1. Urology Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
    2. Urology Institute, University Hospitals Case Medical Center, Department of Urology, Case Western Reserve University, Cleveland, OH, USA
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  • Abdolrasoul Mehrsai MD,

    Corresponding author
    1. Urology Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
    • Corresponding Author: Abdolrasoul Mehrsai, MD, Urology Research Center, Sina Hospital, Hassan-Abad Sq., Tehran 1136746911, Iran. Tel: +98 21 66348560; Fax: +98 21 66348561; E-mail: mehrsai@yahoo.com

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  • Reza Heydari MD,

    1. Urology Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
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  • Gholamreza Pourmand MD

    1. Urology Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
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Abstract

Introduction

Serum uric acid (UA) is now beginning to be considered a risk predictor for cardiovascular diseases. However, little is known about the effect of hyperuricemia on the risk of developing other systemic vascular disorders, especially erectile dysfunction (ED).

Aim

To evaluate whether serum UA is a predicting factor for ED while adjusting for other common risk factors.

Methods

Two hundred fifty-one patients aged 45.2 ± 10.1 years with newly diagnosed and documented ED and 252 age-matched participants without ED (aged 45.1 ± 8.4 years) were enrolled in this case–control study. Univariate and multivariate logistic regression analysis were performed to assess the effect of serum UA on ED; odds ratio (OR) and 95% confidence interval (CI) were calculated. Adjustments were made for potential confounding factors, including obesity, hypertension, diabetes, dyslipidemia, serum triglyceride, and smoking.

Main Outcome Measurement

Serum UA concentration and the distribution of potential ED risk factors (age, smoking, lipid profile, hypertension, obesity, and diabetes mellitus) were evaluated. Serum UA levels were organized into tertiles. The five-item International Index of Erectile Function was used to evaluate the presence and the severity of ED.

Results

The mean serum UA levels in ED-positive and ED-negative groups were 6.12 ± 1.55 mg/dL and 4.97 ± 1.09 mg/dL, respectively (P < 0.001). On analysis of unadjusted variables, statistically significant differences were found for all variables, including serum UA, between ED-positive and ED-negative groups. After adjustment for major risk factors, a significant trend of increasing risk was found for serum UA concentration (OR 5.95, 95% CI 2.96–11.97; P < 0.001, comparing the highest with the lowest tertile). An increase of 1 mg/dL in serum UA level was associated with an approximately twofold increase in risk of ED (OR 2.07; 95% CI 1.63–2.64).

Conclusions

Our findings reveal that serum UA can be considered a risk predictor for ED. Furthermore, hyperuricemia can be regarded as an independent risk factor in addition to the established ones. Salem S, Mehrsai A, Heydari R, and Pourmand G. Serum uric acid as a risk predictor for erectile dysfunction. J Sex Med 2014;11:1118–1124.

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