- Top of page
- FXIII deficiency
- FXIII and pregnancy
- FXIII in wound healing, angiogenesis and atherosclerosis
- The role of FXIII in bone metabolism and bone disease
- Significance of FXIII antigen levels in severe trauma and surgery
- FXIII as part of the insulin resistance syndrome
- FXIII and immune defense and inflammation
- FXIII in neoplasm
- Novel functions of FXIII
- Concluding remarks
- Disclosure of Conflict of Interest
To cite this article: Schroeder V, Kohler HP. New developments in the area of factor XIII. J Thromb Haemost 2013; 11: 234–44.
Summary. Coagulation factor (F)XIII is best known for its role in fibrin stabilization and cross-linking of antifibrinolytic proteins to the fibrin clot. From patients with congenital FXIII deficiency, it is known that FXIII also has important functions in wound healing and maintaining pregnancy. Over the last decade more and more research groups with different backgrounds have studied FXIII and have unveiled putative novel functions for FXIII. FXIII, with its unique role as a transglutaminase among the other serine protease coagulation factors, is now recognized as a multifunctional protein involved in regulatory mechanisms and construction and repair processes beyond hemostasis with possible implications in many areas of medicine. The aim of this review was to give an overview of exciting novel findings and to highlight the remarkable diversity of functions attributed to FXIII. Of course, more research into the underlying mechanisms and (patho-)physiological relevance of the many described functions of FXIII is needed. It will be exciting to observe future developments in this area and to see if and how these interesting findings may be translated into clinical practice in the future.