Synthetic microvessels

Authors

  • J. A. López,

    Corresponding author
    1. Puget Sound Blood Center Research Institute, Seattle, WA, USA
    2. Department of Medicine, Seattle, WA, USA
    3. Department of Biochemistry, Seattle, WA, USA
    • Correspondence: José A. López, Puget Sound Blood Center, 921 Terry Ave., Seattle, WA 98104, USA.

      Tel.: +1 206 568 2202; fax: +1 206 587 6056.

      E-mail: josel@psbcresearch.org

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  • Y. Zheng

    1. Department of Bioengineering, Seattle, WA, USA
    2. Center for Cardiovascular Biology, Institute of Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA
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Summary

The microvasculature is an immense organ that defines the environmental conditions within tissues in both health and disease, and is vital for the proper functions of all tissues. Here, we describe existing tools to study vascular cell function and our work using one platform of in vitro microvessels, which we employed to study vessel structure and remodeling, endothelial barrier function, angiogenesis, interactions between endothelial cells and perivascular cells, interactions between blood cells and the endothelium, and microvascular thrombosis. We also briefly discuss the potential future applications of these platforms in biology and medicine.

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