Manuscript handled by: W. Ruf
Protein disulfide isomerase in thrombosis and vascular inflammation
Article first published online: 10 DEC 2013
© 2013 International Society on Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis
Volume 11, Issue 12, pages 2084–2091, December 2013
How to Cite
Protein disulfide isomerase in thrombosis and vascular inflammation. J Thromb Haemost 2013; 11: 2084–91. DOI: 10.1111/jth.12413.
Final decision: P. H. Reitsma, 13 September 2013
- Issue published online: 10 DEC 2013
- Article first published online: 10 DEC 2013
- Accepted manuscript online: 30 SEP 2013 09:12AM EST
- Manuscript Received: 25 JUL 2013
- National Institutes of Health and the American Heart Association
- protein disulfide isomerase;
Protein disulfide isomerase (PDI) catalyzes disulfide bond oxidation, reduction and isomerization during protein synthesis in the endoplasmic reticulum (ER). In addition to its critical role in the ER, in vitro and in vivo studies with blocking antibodies and conditional knockout mice have demonstrated that cell surface PDI is required for thrombosis, hemostasis and vascular inflammation in a manner dependent on its isomerase activity. This review will focus on our current understanding of the pathophysiologic role of PDI in regulating integrin-mediated platelet and neutrophil functions during vascular disease.