Manuscript handled by: M. Cushman
Antigen levels of coagulation factor XII, coagulation factor XI and prekallikrein, and the risk of myocardial infarction and ischemic stroke in young women
Article first published online: 22 MAY 2014
© 2014 International Society on Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis
Volume 12, Issue 5, pages 606–613, May 2014
How to Cite
Antigen levels of coagulation factor XII, coagulation factor XI and prekallikrein, and the risk of myocardial infarction and ischemic stroke, in young women. J Thromb Haemost 2014; 12: 606–13., , .
Final decision: M. Cushman, 29 January 2014
- Issue published online: 22 MAY 2014
- Article first published online: 22 MAY 2014
- Accepted manuscript online: 21 FEB 2014 01:31PM EST
- Manuscript Accepted: 29 JAN 2014
- Manuscript Received: 6 AUG 2013
- the Netherlands Heart Foundation, The Netherlands. Grant Numbers: 1997.063, 2001.069, 2005B060
- Prevention Fund, The Netherlands. Grant Number: 28-2879
- coagulation factors;
- factor XII;
- myocardial infarction;
High levels of activated protein–inhibitor complexes of the intrinsic coagulation proteins are associated with ischemic stroke (IS) but not with myocardial infarction (MI). This study was aimed at determining whether the antigen levels of coagulation factors (factor XII, FXII, and FXI and prekallikrein (PK) are associated with MI and IS, and whether this association is independent of levels of activated protein–inhibitor complexes.
Patients and Methods
The RATIO study included young women (< 50 years) with MI (N = 205) and IS (N = 175), and 638 healthy controls. Antigen levels of FXII, FXI and PK were measured and expressed as percentages of of those in pooled normal plasmas. Odds ratios (ORs) and corresponding 99% confidence intervals (CIs) were calculated for high levels (i.e. ≥ 90th percentile of controls) as measures of rate ratios.
After adjustment for potential confounders, high levels of FXII antigen were not associated with MI risk or IS risk (ORMI 1.18, 99% CI 0.51–2.74; ORIS 1.03, 9% CI 0.41–2.55). High levels of FXI antigen were slightly associated with an increase in MI risk (ORMI 1.55, 9% CI 0.74–3.21), whereas there was a substantial association with IS risk (ORIS 2.65, 9% CI 1.27–5.56). PK antigen was slightly associated with MI risk but not with IS risk (ORMI 1.54, 9% CI 0.67–3.52; ORIS 0.90, 9% CI 0.35–2.33). All associations remained similar after adjustment for levels of protein–inhibitor complexes.
Increased levels of FXI antigen were associated with an increase in IS risk, whereas they showed only a marginal association with MI risk. FXII antigen and PK antigen levels were not substantially associated with MI risk and IS risk.