Corynebacterium diphtheriae and the Returned Tropical Traveler
Article first published online: 8 NOV 2013
© 2013 International Society of Travel Medicine
Journal of Travel Medicine
Volume 21, Issue 1, pages 39–44, January/February 2014
How to Cite
May, M. L.A., McDougall, R. J. and Robson, J. M. (2014), Corynebacterium diphtheriae and the Returned Tropical Traveler. Journal of Travel Medicine, 21: 39–44. doi: 10.1111/jtm.12074
- Issue published online: 3 JAN 2014
- Article first published online: 8 NOV 2013
- Manuscript Accepted: 15 AUG 2013
- Manuscript Revised: 12 AUG 2013
- Manuscript Received: 20 MAY 2013
In Western countries, nontoxigenic Corynebacterium diphtheriae is known to cause skin and soft tissue infections (SSIs), upper respiratory tract infections, and occasionally invasive disease. Its role as a skin pathogen in returned travelers from tropical destinations where the organism is endemic is often forgotten. A retrospective analysis of a large Australian private pathology laboratory's experience with C. diphtheriae was performed to identify how frequently overseas travel was associated with C. diptheriae infection/colonization.
All C. diphtheriae isolates cultured from 2002 to 2012 were reviewed. Recorded clinical information regarding recent travel, country, and cause of infection was assessed. Antibiotic susceptibility was verified on all isolates.
In all there were 72 patients who had C. diphtheriae isolated on clinical specimens, and information about prior travel was available for 63. Seventy percent of these were healthy individuals with an SSI and history of recent travel to a tropical nation. Ninety-seven percent had associated copathogens. Two isolates were penicillin resistant. There was uniform susceptibility to cephalothin, clindamycin, erythromycin, and vancomycin, with 14% resistance to trimethoprim/sulfamethoxazole and 4% resistance to tetracycline. Only one isolate was a toxigenic strain.
The majority of C. diphtheriae isolated were from SSIs in otherwise healthy travelers returning from tropical destinations, rather than classical risk groups. Clinicians and laboratories need to be aware of this potential source of C. diphtheriae infection due to rare toxigenic strains.