Complementary laboratory indices for predicting the disease status of patients with hepatitis B virus infection

Authors

  • F. Chen,

    1. State Key Laboratory of Infectious Disease Diagnosis and Treatment, First Affiliated Hospital, College of Medicine, Zhejiang University, Key Laboratory of Infectious Diseases, Zhejiang, China
    Search for more papers by this author
  • J. L. He,

    1. Institute of Environmental Medicine, School of Public Health, Zhejiang University, Hangzhou, China
    Search for more papers by this author
  • M. Zheng,

    1. State Key Laboratory of Infectious Disease Diagnosis and Treatment, First Affiliated Hospital, College of Medicine, Zhejiang University, Key Laboratory of Infectious Diseases, Zhejiang, China
    Search for more papers by this author
  • H. H. Zhu,

    1. State Key Laboratory of Infectious Disease Diagnosis and Treatment, First Affiliated Hospital, College of Medicine, Zhejiang University, Key Laboratory of Infectious Diseases, Zhejiang, China
    Search for more papers by this author
  • S. P. Li,

    1. State Key Laboratory of Infectious Disease Diagnosis and Treatment, First Affiliated Hospital, College of Medicine, Zhejiang University, Key Laboratory of Infectious Diseases, Zhejiang, China
    Search for more papers by this author
  • K. Wang,

    1. Qilu Hospital of Shandong University, Jinan, China
    Search for more papers by this author
  • X. X. Zhang,

    1. Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Search for more papers by this author
  • Y. R. Zhao,

    1. The First Affiliated Hospital of Medical College of Xian Jiaotong University, Xian, China
    Search for more papers by this author
  • S. S. Wu,

    1. State Key Laboratory of Infectious Disease Diagnosis and Treatment, First Affiliated Hospital, College of Medicine, Zhejiang University, Key Laboratory of Infectious Diseases, Zhejiang, China
    Search for more papers by this author
  • Z. Chen

    Corresponding author
    • State Key Laboratory of Infectious Disease Diagnosis and Treatment, First Affiliated Hospital, College of Medicine, Zhejiang University, Key Laboratory of Infectious Diseases, Zhejiang, China
    Search for more papers by this author

Correspondence: Zhi Chen, State Key Laboratory of Infectious Disease Diagnosis and Treatment, First Affiliated Hospital, College of Medicine, Zhejiang University, Key Laboratory of Infectious Diseases, Zhejiang Province, 310003 China.

E-mail: zju.zhichen@gmail.com

Summary

To identify complementary laboratory indices for determining the disease status of patients with hepatitis B virus. Subjects were divided into six groups: hepatitis B virus carrier, mild chronic hepatitis B, moderate chronic hepatitis B, severe chronic hepatitis B, fulminant hepatitis B and healthy controls. Serum alanine aminotransferase, total bilirubin and direct bilirubin were measured by an automatic analyser. The levels of T-cell immunoglobulin domain and mucin-domain-containing molecule-3, macrophage inflammatory protein 2, neutrophil gelatinase-associated lipocalin and inducible nitric oxide synthase were measured by ELISA. T-cell immunoglobulin domain, mucin-domain-containing molecule-3, macrophage inflammatory protein 2 and inducible nitric oxide synthase levels were significantly higher in patients with severe chronic hepatitis B compared with those in patients with mild and moderate chronic hepatitis B or fulminant hepatitis B (< 0.05). When normal or abnormal alanine aminotransferase was present, significant differences between macrophage inflammatory protein 2 and T-cell immunoglobulin domain and mucin-domain-containing molecule-3 levels between patients with mild, moderate, severe chronic hepatitis B or fulminant hepatitis B were observed (< 0.05). Our results suggest that T-cell immunoglobulin domain and mucin-domain-containing molecule-3 and macrophage inflammatory protein 2 could serve as alanine aminotransferase, direct bilirubin or total bilirubin complementary indices for determining the status of patients with hepatitis B.

Ancillary