jvh12208-sup-0001-FigS1.pdfapplication/PDF622KFigure S1: Impairment of insulin-induced Akt phosphorylation in CHC liver biopsies. Control (n = 2) and CHC (n = 3) liver biopsies were incubated ex vivo with 100 nm insulin for 15 min. Phosphorylation of Akt was then visualized by immunoblotting.
jvh12208-sup-0002-FigS2.pdfapplication/PDF244KFigure S2: Proposed model of regulation of G6Pase transcription by HCV-mediated PP2Ac upregulation. HCV infection induces an ER stress response leading to the activation of CREB. Activated CREB upregulates PP2Ac and PGC1α. PGC1α interacts with FoxO1 to modulate the transcriptional activity of FoxO1. PP2Ac impairs insulin-mediated Akt activation and/or directly associates to FoxO1 preventing its phosphorylation. Consequently, FoxO1 phosphorylation is reduced and thus enhances G6Pase transcription.

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