This work was performed at Colorado State University, Fort Collins, CO.
Milk Thistle and Its Derivative Compounds: A Review of Opportunities for Treatment of Liver Disease
Article first published online: 9 NOV 2012
Copyright © 2012 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 27, Issue 1, pages 10–16, January/February 2013
How to Cite
Hackett, E.S., Twedt, D.C. and Gustafson, D.L. (2013), Milk Thistle and Its Derivative Compounds: A Review of Opportunities for Treatment of Liver Disease. Journal of Veterinary Internal Medicine, 27: 10–16. doi: 10.1111/jvim.12002
This study was not supported by grant funding.
This article has not been presented at a professional meeting
- Issue published online: 11 JAN 2013
- Article first published online: 9 NOV 2012
- Manuscript Accepted: 18 SEP 2012
- Manuscript Revised: 18 AUG 2012
- Manuscript Received: 9 AUG 2012
Milk thistle extracts have been used as a “liver tonic” for centuries. In recent years, silibinin, the active ingredient in milk thistle extracts, has been studied both in vitro and in vivo to evaluate the beneficial effects in hepatic disease. Silibinin increases antioxidant concentrations and improves outcomes in hepatic diseases resulting from oxidant injury. Silibinin treatment has been associated with protection against hepatic toxins, and also has resulted in decreased hepatic inflammation and fibrosis. Limited information currently is available regarding silibinin use in veterinary medicine. Future study is justified to evaluate dose, kinetics, and treatment effects in domestic animals.