All work was performed at the Matthew J. Ryan Veterinary Hospital of the University of Pennsylvania, 3900 Delancey St, Philadelphia PA 19104.
Prospective Clinical Trial to Compare Vincristine and Vinblastine in a COP-Based Protocol for Lymphoma in Cats
Article first published online: 17 NOV 2012
Copyright © 2012 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 27, Issue 1, pages 134–140, January/February 2013
How to Cite
Krick, E.L., Cohen, R.B., Gregor, T.P., Salah (Griessmayr), P.C. and Sorenmo, K.U. (2013), Prospective Clinical Trial to Compare Vincristine and Vinblastine in a COP-Based Protocol for Lymphoma in Cats. Journal of Veterinary Internal Medicine, 27: 134–140. doi: 10.1111/jvim.12006
This research was presented as an oral abstract presentation at the 30th annual Veterinary Cancer Society Conference, San Diego, CA, October 2010.
- Issue published online: 11 JAN 2013
- Article first published online: 17 NOV 2012
- Manuscript Accepted: 25 SEP 2012
- Manuscript Revised: 20 AUG 2012
- Manuscript Received: 21 MAY 2012
- Clinical Oncology Research Fund of the Veterinary Hospital of the University of Pennsylvania
- a University of Pennsylvania School of Veterinary Medicine Department of Clinical Studies Research Grant
- Vinca alkaloid
Current standard chemotherapy protocols for lymphoma in cats carry risks of gastrointestinal toxicity, which can decrease quality of life and complicate response assessment. Protocols with less gastrointestinal toxicity may improve treatment tolerance.
The study purpose was to compare response rate, outcome, and toxicity between cats that received vincristine or vinblastine as part of combination chemotherapy for lymphoma. We hypothesized that vinblastine would have similar efficacy, but less gastrointestinal toxicity, compared with vincristine.
Forty client-owned cats with confirmed diagnosis of lymphoma.
Cats were randomized to 1 of 2 treatment arms and received weekly COP-based chemotherapy for 6 months or until disease progression. Response rate, progression-free survival (PFS), lymphoma-specific survival (LSS), and incidence and severity of gastrointestinal and hematologic toxicity were compared between arms. Arm cross-over occurred if specific gastrointestinal toxicity criteria were noted.
Cats in both arms had similar response rates, PFS, and LSS (48 versus 64 days, P = .87; 139 versus 136 days, P = .96). Cats that received vincristine were significantly more likely to switch arms based on gastrointestinal toxicity than cats that received vinblastine (44.4 versus 10.5%, P = .02). Lower baseline weight was significantly negatively associated with PFS and LSS (P = .01, P = .003, respectively). Baseline anemia was significantly negatively associated with LSS (P = .04).
Conclusions and Clinical Importance
Results suggest that vinblastine is a reasonable alternative to vincristine in the treatment of some cats with lymphoma. Baseline body weight remains a significant prognostic factor for cats with lymphoma.