Elevated Serum Cardiac Troponin I in Cattle with Theileriosis
Article first published online: 27 NOV 2012
Copyright © 2012 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 27, Issue 1, pages 194–199, January/February 2013
How to Cite
Fartashvand, M., Nadalian, M.G., Sakha, M. and Safi, S. (2013), Elevated Serum Cardiac Troponin I in Cattle with Theileriosis. Journal of Veterinary Internal Medicine, 27: 194–199. doi: 10.1111/jvim.12014
- Issue published online: 11 JAN 2013
- Article first published online: 27 NOV 2012
- Manuscript Accepted: 9 OCT 2012
- Manuscript Revised: 27 JUN 2012
- Manuscript Received: 18 OCT 2011
- AST ;
- Cardiac markers;
- Cardiac troponin I;
- Hemolytic anemia;
- Theileria annulata
Theileria annulata is a blood parasite affecting ruminants. Hemolytic anemia, secondary hypoxia, and vasculitis are the most important features of tropical theileriosis.
Evaluation of electrocardiographic findings and changes in cardiovascular biochemical markers including cTnI concentrations in cattle naturally infected with theileriosis in the absence of acute cardiac failure.
Ninety adult Holstein cattle (>1 year) with clinical and laboratory evidence of theileriosis and 30 healthy cattle served as controls.
Case-control study in which blood samples were collected and randomized after clinical, hematologic, parasitologic examination and laboratory confirmation and electrocardiographic recording on all animals, serum cardiac troponin I (cTnI), aspartate aminotransferase (AST), and creatine kinase-MB (CK-MB) were evaluated.
Serum concentration of cTnI was significantly higher in cattle with theileriosis (mean: 0.028 ng/mL; range: 0.005–0.21 ng/mL; control mean: 0.011; range: <0.005–0.09 ng/mL; P = .003). There was significant correlation between serum level of cTnI and PCV (r = −0.257; P < .001) and also between cTnI and parasitemia (r = 0.515; P < .001). Mean serum activities of AST and CK-MB were 107 ± 46 and 301 ± 103 U/L in sick animals, which were significantly higher than healthy cattle (P = .002 and P = .041, respectively). There were no pathologic arrhythmias detected in sick animals.
Conclusions and Clinical Importance
Theileriosis is a risk factor for elevation of cardiac biomarkers in naturally infected Holstein cattle. Severity of anemia and parasitemia might contribute to the pathophysiology of myocardial damage. The prognostic significance of increased serum cardiac troponin I concentrations in cattle with hemolytic anemia merits further investigation.