Presented at the 2011 Meeting of the Equine Science Society, Murfreesboro, TN June 2011
Relationships between Body Condition Score and Plasma Inflammatory Cytokines, Insulin, and Lipids in a Mixed Population of Light-Breed Horses
Article first published online: 6 DEC 2012
Copyright © 2012 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 27, Issue 1, pages 157–163, January/February 2013
How to Cite
Suagee, J.K., Corl, B.A., Crisman, M.V., Pleasant, R.S., Thatcher, C.D. and Geor, R.J. (2013), Relationships between Body Condition Score and Plasma Inflammatory Cytokines, Insulin, and Lipids in a Mixed Population of Light-Breed Horses. Journal of Veterinary Internal Medicine, 27: 157–163. doi: 10.1111/jvim.12021
- Issue published online: 11 JAN 2013
- Article first published online: 6 DEC 2012
- Manuscript Accepted: 23 OCT 2012
- Manuscript Revised: 13 SEP 2012
- Manuscript Received: 28 MAR 2012
- Virginia Horse Industry Board
- Paul Mellon
- National Science Foundation. Grant Number: DGE-0333378
- Serum amyloid A;
- Tumor necrosis factor
Obesity and hyperinsulinemia increase the risk of laminitis in horses and ponies. In mares, obesity also has been associated with increased circulating concentrations of the proinflammatory cytokine, tumor necrosis factor (TNF)-α. The association of other proinflammatory cytokines with body condition score (BCS) and insulin requires further determination.
Plasma concentrations of TNF, interleukin (IL)-1β, IL-6, and serum amyloid A (SAA) will positively correlate with BCS or insulin or both in horses. Furthermore, inflammatory protein concentrations will correlate with age and variables associated with BCS, including plasma insulin, triglycerides, nonesterified fatty acids, and leptin concentrations.
One hundred and ten mixed light-breed horses, including mares, geldings, and stallions, aged 4–20 years.
Samples were selected from a larger population of plasma samples previously collected during June–July of 2006. Samples were analyzed for TNF, IL-1β, IL-6, and SAA using commercially available ELISAs and simple correlations were used to determine relationships with BCS, insulin, age, and sex.
Plasma TNF (P = .047) and IL-6 (P = .021) concentrations were higher in females than males, whereas IL-6 concentrations correlated (P = .001) with age. Plasma SAA concentrations correlated with both insulin (P < .001) and BCS (P = .007).
Conclusions and Clinical Importance
This study provides evidence for factors, including age and sex, that may be associated with plasma concentrations of inflammatory proteins. Concentrations of SAA correlated with BCS and insulin, independent of age or sex. Because BCS and insulin correlate with increased SAA, it is possible that SAA is a component of laminitis pathophysiology.