This study was carried out at the Clinic for Swine, Small Ruminants, Forensic Medicine and Ambulatory Service, University of Veterinary Medicine Hannover, and the Institute of Farm Animal Genetics, Friedrich-Loeffler-Institute (FLI) Federal Research Institute for Animal Health, Neustadt, Germany.
Insulin Sensitivity during Late Gestation in Ewes Affected by Pregnancy Toxemia and in Ewes with High and Low Susceptibility to this Disorder
Article first published online: 9 FEB 2013
Copyright © 2013 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 27, Issue 2, pages 359–366, March/April 2013
How to Cite
Duehlmeier, R., Fluegge, I., Schwert, B. and Ganter, M. (2013), Insulin Sensitivity during Late Gestation in Ewes Affected by Pregnancy Toxemia and in Ewes with High and Low Susceptibility to this Disorder. Journal of Veterinary Internal Medicine, 27: 359–366. doi: 10.1111/jvim.12035
This study was supported by the German Research Organization (DFG) grant SA 160/17 - 2.
Results of this trial were presented at the 7th International Sheep Veterinary Congress, Stavanger, Norway, June 12–16, 2009 and at the International Conference on Small Ruminant Health Management, Sellin, Germany, May 23–25, 2012.
- Issue published online: 15 MAR 2013
- Article first published online: 9 FEB 2013
- Manuscript Accepted: 28 NOV 2012
- Manuscript Revised: 16 AUG 2012
- Manuscript Received: 22 MAR 2012
- Insulin resistance;
- Pregnancy toxemia;
Insulin resistance during late gestation might act as 1 etiologic factor causing pregnancy toxemia in ewes.
Evaluation of pancreatic insulin secretion and peripheral insulin sensitivity in ewes with differing susceptibility to pregnancy toxemia and in ketotic ewes.
Pregnant ewes suffering from (PT, n = 5) and ewes with high (HR, n = 7) and low risk (LR, n = 5) of being affected by pregnancy toxemia.
In a case-control study, the pancreatic insulin release and the peripheral insulin sensitivity were assessed by means of the intravenous glucose tolerance test with subsequent measurement of the plasma concentrations of glucose, insulin, nonesterified fatty acids (NEFA), and β-hydroxybutyrate (β-HB). The ewes were tested during late pregnancy within 5 and 15 days antepartum.
The insulin secretion after glucose administration was significantly lower in the HR and PT than in the LR ewes. The baseline rate of lipolysis was significantly increased in the HR ewes, but the NEFA clearance was similar in both risk groups, albeit delayed in the PT ewes. The baseline β-HB concentration was significantly higher in the PT than in the HR and LR ewes. In the HR and in the PT ewes, the plasma β-HB concentrations did not decrease after glucose administration.
Conclusion and Clinical Importance
There is reduced pancreatic first-phase insulin response and impaired insulin-dependent inhibition of the ketone body formation during late pregnancy in the HR and PT ewes. This insulin resistance might represent 1 causative factor in the pathogenesis of ovine pregnancy toxemia.