Fibroblast Growth Factor 23 (FGF-23) Concentrations in Cats with Early Nonazotemic Chronic Kidney Disease (CKD) and in Healthy Geriatric Cats
Article first published online: 30 JAN 2013
Copyright © 2013 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 27, Issue 2, pages 227–233, March/April 2013
How to Cite
Finch, N.C., Geddes, R.F., Syme, H.M. and Elliott, J. (2013), Fibroblast Growth Factor 23 (FGF-23) Concentrations in Cats with Early Nonazotemic Chronic Kidney Disease (CKD) and in Healthy Geriatric Cats. Journal of Veterinary Internal Medicine, 27: 227–233. doi: 10.1111/jvim.12036
- Issue published online: 15 MAR 2013
- Article first published online: 30 JAN 2013
- Manuscript Accepted: 27 NOV 2012
- Manuscript Revised: 28 SEP 2012
- Manuscript Received: 1 MAY 2012
- GFR ;
- Renal secondary hyperparathyroidism
Fibroblast growth factor (FGF-23) has an important role in phosphate regulation. Its clinical relevance in cats with CKD has not been explored previously.
The study objectives were (1) to determine whether FGF-23 concentrations are increased in nonazotemic cats, cats which developed azotemia within 12 months of screening compared with cats that remained non-azotemic, and (2) to evaluate the relationships between FGF-23 and PTH and FGF-23 and glomerular filtration rate (GFR).
Sixty-two healthy client-owned geriatric cats, 14 of which developed azotemia during the 12-month follow-up period.
Healthy nonazotemic cats were recruited prospectively into the study and followed for 12 months. At the study end-point, cats were categorized into 3 groups according to plasma creatinine concentration. PTH, FGF-23, and additional biochemical variables were evaluated at baseline and after 12 months. GFR was measured by a corrected slope-intercept iohexol clearance method.
FGF-23 concentrations at baseline were found to be significantly increased in cats that developed azotemia (P = .001) compared with cats that did not develop azotemia. A significant positive relationship was identified between FGF-23 and PTH, whereas the relationship between FGF-23 and GFR was negative.
Conclusions and Clinical Importance
FGF-23 concentrations predicted development of azotemia in geriatric cats. Positive relationships between FGF-23 and PTH suggest an association between FGF-23 and renal secondary hyperparathyroidism.