Work was completed at Charles Sturt University. Pharmacologic analysis of collected samples was performed at Troy Laboratories.
Pharmacokinetics and Safety of Oral Administration of Meloxicam to Foals
Article first published online: 20 FEB 2013
Copyright © 2013 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 27, Issue 2, pages 300–307, March/April 2013
How to Cite
Raidal, S.L., Edwards, S., Pippia, J., Boston, R. and Noble, G.K. (2013), Pharmacokinetics and Safety of Oral Administration of Meloxicam to Foals. Journal of Veterinary Internal Medicine, 27: 300–307. doi: 10.1111/jvim.12045
Preliminary findings have been presented at the American Association of Equine Practitioners Annual Conference, Las Vegas, December 2009
- Issue published online: 15 MAR 2013
- Article first published online: 20 FEB 2013
- Manuscript Accepted: 3 JAN 2013
- Manuscript Revised: 1 NOV 2012
- Manuscript Received: 3 NOV 2011
- Troy Laboratories
- COX ;
- Gastric ulceration;
- Nonsteroidal anti-inflammatory drugs;
- Right dorsal colitis
The pharmacokinetics, efficacy, and safety of meloxicam have been evaluated in adult horses, but not foals. Physiologic differences between neonates and adults might alter drug pharmacokinetics and therapeutic index.
The pharmacokinetics of meloxicam will be different in foals compared with adult horses, and foals could be at increased risk for adverse drug effects.
Twenty lightbreed foals less than 6 weeks of age at commencement of the study.
Single and repeated oral dose pharmacokinetics were determined for meloxicam (0.6 mg/kg) in 10 foals. The safety of the drug was further evaluated in a 2nd group of 10 foals in a randomized blinded prospective study.
Plasma concentrations after a single oral dose of meloxicam (0.6 mg/kg) and time to maximum plasma concentration were similar to adult horses. However, drug clearance was much more rapid in foals (elimination half-life 2.48 ± 0.25 hours). Administration of 0.6 mg/kg every 12 hours was well tolerated by foals for up to 3 weeks, with no evidence of drug accumulation in plasma. Adverse effects observed in adult horses at higher dose rates were not observed in foals given 1.8 mg/kg twice daily for 7 days.
Conclusions and clinical importance
Meloxicam at an oral dose rate of 0.6 mg/kg every 12 hours provided plasma concentrations likely to be therapeutic. In contrast to findings for other NSAIDs, foals appeared more resilient to the adverse effects of this drug than was observed in adult horses.